IFOM, The FIRC Institute of Molecular Oncology, Milan 20139, Italy; Oncology and Haemato-Oncology Department, University of Milan, Milan 20122, Italy.
Curr Opin Cell Biol. 2023 Oct;84:102222. doi: 10.1016/j.ceb.2023.102222. Epub 2023 Aug 22.
The mechanical properties of the nucleus influence different cellular and nuclear functions and have relevant implications for several human diseases. The nucleus protects genetic information while acting as a mechano-sensory hub in response to internal and external forces. Cells have evolved mechano-transduction signaling to respond to physical cellular and nuclear perturbations and adopted a multitude of molecular pathways to maintain nuclear shape stability and prevent morphological abnormalities of the nucleus. Here we describe those key biological processes that control nuclear mechanics and discuss emerging perspectives on the mechanobiology of the nucleus as a diagnostic tool and clinical target.
核的机械特性影响着不同的细胞和核功能，并对几种人类疾病具有重要意义。核在保护遗传信息的同时，作为一个机械感应中心，对内部和外部力量作出反应。细胞已经进化出机械转导信号，以响应物理细胞和核的扰动，并采用了多种分子途径来维持核的形状稳定性，防止核的形态异常。在这里，我们描述了控制核力学的那些关键生物学过程，并讨论了核的机械生物学作为一种诊断工具和临床靶点的新视角。
