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用于淋巴成像和治疗的纳米医学进展。

Advances in nanomedicines for lymphatic imaging and therapy.

机构信息

Department of Hepatobiliary Surgery, Academician (Expert) Workstation, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637600, China.

State Key Laboratory of Vaccines for Infectious Diseases, Center for Molecular Imaging and Translational Medicine, Xiang An Biomedicine Laboratory, National Innovation Platform for Industry-Education Integration in Vaccine Research, School of Public Health, Xiamen University, Xiamen, 361002, China.

出版信息

J Nanobiotechnology. 2023 Aug 24;21(1):292. doi: 10.1186/s12951-023-02022-x.

DOI:10.1186/s12951-023-02022-x
PMID:37620846
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10463797/
Abstract

Lymph nodes play a pivotal role in tumor progression as key components of the lymphatic system. However, the unique physiological structure of lymph nodes has traditionally constrained the drug delivery efficiency. Excitingly, nanomedicines have shown tremendous advantages in lymph node-specific delivery, enabling distinct recognition and diagnosis of lymph nodes, and hence laying the foundation for efficient tumor therapies. In this review, we comprehensively discuss the key factors affecting the specific enrichment of nanomedicines in lymph nodes, and systematically summarize nanomedicines for precise lymph node drug delivery and therapeutic application, including the lymphatic diagnosis and treatment nanodrugs and lymph node specific imaging and identification system. Notably, we delve into the critical challenges and considerations currently facing lymphatic nanomedicines, and futher propose effective strategies to address these issues. This review encapsulates recent findings, clinical applications, and future prospects for designing effective nanocarriers for lymphatic system targeting, with potential implications for improving cancer treatment strategies.

摘要

淋巴结在肿瘤进展中起着关键作用，是淋巴系统的重要组成部分。然而，淋巴结独特的生理结构传统上限制了药物输送效率。令人兴奋的是，纳米医学在淋巴结特异性递送上显示出巨大的优势，能够对淋巴结进行独特的识别和诊断，从而为高效的肿瘤治疗奠定了基础。在这篇综述中，我们全面讨论了影响纳米药物在淋巴结中特异性富集的关键因素，并系统地总结了用于精确淋巴结药物输送和治疗应用的纳米药物，包括淋巴诊断和治疗纳米药物以及淋巴结特异性成像和识别系统。值得注意的是，我们深入探讨了当前淋巴纳米医学面临的关键挑战和考虑因素，并进一步提出了有效的策略来解决这些问题。这篇综述总结了最近的发现、临床应用和未来设计针对淋巴系统的有效纳米载体的前景，这可能对改善癌症治疗策略有重要意义。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23ca/10463797/d4b1c87583f0/12951_2023_2022_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23ca/10463797/af674ebb305d/12951_2023_2022_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23ca/10463797/bd04831fd968/12951_2023_2022_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23ca/10463797/762d1476761e/12951_2023_2022_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23ca/10463797/2eac8d8df906/12951_2023_2022_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23ca/10463797/47bc2a9233ca/12951_2023_2022_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23ca/10463797/10d2e4ae1825/12951_2023_2022_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23ca/10463797/33e6ee639897/12951_2023_2022_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23ca/10463797/0d4875d174e1/12951_2023_2022_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23ca/10463797/35bcbcb62ec7/12951_2023_2022_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23ca/10463797/78a11391a61f/12951_2023_2022_Fig11_HTML.jpg

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