Limeback Hardy, Enax Joachim, Meyer Frederic
Faculty of Dentistry, University of Toronto, Toronto, ON M5G1G6, Canada.
Dr. Kurt Wolff GmbH & Co. KG, Research Department, Johanneswerkstr. 34-36, 33611 Bielefeld, Germany.
Biomimetics (Basel). 2023 Jan 6;8(1):23. doi: 10.3390/biomimetics8010023.
Dentin hypersensitivity (DH) is a very common dental problem that can have a negative impact on the quality of life and can lead to invasive dental procedures. Prevention of DH and control of symptoms are highly desirable. Hydroxyapatite (HAP) has been shown in vitro to block dentinal tubules and in vivo to be a safe and effective additive in oral care products that reduce DH clinically. This study's aim was to conduct a systematic review and meta-analysis of the current evidence that HAP-containing oral care products reduce DH. Databases were searched, and only clinical trials in humans were included; studies conducted in vitro or on animals were not included. Publications in a foreign language were translated and included. We found 44 published clinical trials appropriate for systematic analysis. More than half of the trials had high-quality GRADE scores. HAP significantly reduced dentin hypersensitivity compared to placebo (39.5%; CI 95% [48.93; 30.06]), compared to fluoride (23%; CI 95% [34.18; 11.82]), and with a non-significant tendency compared to other desensitizing agents (10.2%; CI 95% [21.76; -19.26]). In conclusion, the meta-analysis showed that HAP added to oral care products is a more effective agent than fluoride in controlling dentin hypersensitivity and may be superior to other desensitizers.
牙本质过敏症（DH）是一种非常常见的牙科问题，会对生活质量产生负面影响，并可能导致侵入性牙科治疗。预防牙本质过敏症和控制症状非常必要。羟基磷灰石（HAP）在体外已被证明可封闭牙本质小管，在体内已被证明是口腔护理产品中一种安全有效的添加剂，可在临床上减轻牙本质过敏症。本研究的目的是对目前关于含HAP的口腔护理产品减轻牙本质过敏症的证据进行系统评价和荟萃分析。我们检索了数据库，仅纳入了人体临床试验；未纳入体外或动物研究。对外语出版物进行了翻译并纳入。我们发现44项已发表的临床试验适合进行系统分析。超过一半的试验具有高质量的GRADE评分。与安慰剂相比，HAP能显著降低牙本质过敏症（39.5%；95%置信区间[48.93；30.06]），与氟化物相比（23%；95%置信区间[34.18；11.82]），与其他脱敏剂相比有不显著的趋势（10.2%；95%置信区间[21.76；-19.26]）。总之，荟萃分析表明，添加到口腔护理产品中的HAP在控制牙本质过敏症方面比氟化物更有效，可能优于其他脱敏剂。
