• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

24个月及以下儿童使用的含氟牙膏剂量。

Doses of fluoride toothpaste for children up to 24 months.

作者信息

Sudradjat Henny, Meyer Frederic, Fandrich Pascal, Schulze Zur Wiesche Erik, Limeback Hardy, Enax Joachim

机构信息

Dr. Kurt Wolff GmbH & Co. KG, Research Department, Johanneswerkstr. 34-36, 33611, Bielefeld, Germany.

Private dental practice, Braunschweig, Germany.

出版信息

BDJ Open. 2024 Jan 31;10(1):7. doi: 10.1038/s41405-024-00187-7.

DOI:10.1038/s41405-024-00187-7
PMID:38296947
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10831090/
Abstract

AIM

The aim of this study was to test the dose of fluoride toothpaste by parents for their children aged up to 24 months.

METHODS

Parents who use fluoride toothpastes for their children were asked to dose two commercially available toothpastes (A and B) with 1000 ppm fluoride each for their children as they would normally do at home. The toothpaste amounts were weighed, and as reference, the weight of an 'optimal' grain of rice-size amount of each toothpaste was used.

RESULTS

61 parents dosed a mean of 0.263 ± 0.172 g toothpaste A and 0.281 ± 0.145 g toothpaste B. The parents' mean doses were 5.9 times higher for toothpaste A and 7.2 times higher for toothpaste B than an 'optimal' grain of rice-size amount (the reference dose as recommended). The difference between parent's and reference dose was statistically significant (p < 0.001). Moreover, 39.3% of parents were not aware about conditions of use and warnings that have to be printed on the package of fluoride toothpastes.

CONCLUSION

In this study, parents significantly overdosed the toothpaste for their children. To avoid fluoride intake from toothpaste, parents can choose fluoride-free alternatives for the oral care of their infants and toddlers.

摘要

目的

本研究旨在测试家长给24个月及以下儿童使用含氟牙膏的剂量。

方法

要求那些给孩子使用含氟牙膏的家长,按照他们在家中的常规做法,给孩子使用两种市售含氟牙膏(牙膏A和牙膏B),每种牙膏的氟含量均为1000 ppm。对牙膏用量进行称重,并以每支牙膏“最佳”米粒大小用量的重量作为参考。

结果

61位家长给孩子使用的牙膏A平均剂量为0.263±0.172克,牙膏B平均剂量为0.281±0.145克。家长们使用的牙膏A平均剂量比“最佳”米粒大小用量(推荐的参考剂量)高5.9倍,牙膏B高7.2倍。家长使用剂量与参考剂量之间的差异具有统计学意义(p<0.001)。此外,39.3%的家长不知道含氟牙膏包装上必须印有的使用条件和警告。

结论

在本研究中,家长给孩子使用的牙膏剂量明显过量。为避免孩子从牙膏中摄入氟,家长可为婴幼儿选择不含氟的口腔护理产品。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/432a/10831090/d63c69cb7b20/41405_2024_187_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/432a/10831090/55a6e48d463a/41405_2024_187_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/432a/10831090/65060ff1998e/41405_2024_187_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/432a/10831090/d63c69cb7b20/41405_2024_187_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/432a/10831090/55a6e48d463a/41405_2024_187_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/432a/10831090/65060ff1998e/41405_2024_187_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/432a/10831090/d63c69cb7b20/41405_2024_187_Fig3_HTML.jpg

相似文献

1
Doses of fluoride toothpaste for children up to 24 months.24个月及以下儿童使用的含氟牙膏剂量。
BDJ Open. 2024 Jan 31;10(1):7. doi: 10.1038/s41405-024-00187-7.
2
Fluoride ingestion from toothpaste by young children.幼儿从牙膏中摄入氟化物。
Br Dent J. 1999 May 8;186(9):460-2. doi: 10.1038/sj.bdj.4800140.
3
Association between Level of Parental Oral Health Literacy and the Rational Use of Fluoride for Children from 0 to 4 Years of Age after Instruction: An Intervention Trial.父母口腔健康素养水平与儿童口腔健康的关系:一项干预试验 0 至 4 岁儿童在接受指导后合理使用氟化物
Caries Res. 2022;56(5-6):535-545. doi: 10.1159/000527419. Epub 2022 Nov 16.
4
Fluoride toothpastes of different concentrations for preventing dental caries.不同浓度预防龋齿的含氟牙膏。
Cochrane Database Syst Rev. 2019 Mar 4;3(3):CD007868. doi: 10.1002/14651858.CD007868.pub3.
5
How much is a 'pea-sized amount'? A study of dentifrice dosing by parents in three countries.“豌豆大小的量”是多少?三个国家父母对牙膏剂量的研究。
Int Dent J. 2013 Dec;63 Suppl 2(Suppl 2):25-30. doi: 10.1111/idj.12074.
6
Parents' interpretation of instructions to control the dose of fluoridated toothpaste used with young children.父母对控制幼儿使用含氟牙膏剂量说明的理解。
Pediatr Dent. 2013 May-Jun;35(3):262-6.
7
The rational use of fluoride toothpaste.含氟牙膏的合理使用。
Int J Dent Hyg. 2003 Feb;1(1):3-8. doi: 10.1034/j.1601-5037.2003.00001.x.
8
An assessment of the current status of children's toothpaste in Australia.评估澳大利亚儿童牙膏的现状。
Aust Dent J. 2021 Mar;66 Suppl 1:S56-S62. doi: 10.1111/adj.12855. Epub 2021 Jun 1.
9
A survey on toothbrushing practices and dosing of fluoridated toothpaste among preschool children in the cantons of Basel-Stadt and Berne, Switzerland.瑞士巴塞尔城市州和伯尔尼州学龄前儿童刷牙习惯和含氟牙膏用量的调查。
Swiss Dent J. 2024 Jan 10;133(2):18-34. doi: 10.61872/sdj-2024-07-08-01.
10
Estimated fluoride doses from toothpastes should be based on total soluble fluoride.估算牙膏中的氟化物剂量应基于总可溶性氟化物。
Int J Environ Res Public Health. 2013 Nov 1;10(11):5726-36. doi: 10.3390/ijerph10115726.

引用本文的文献

1
Fluoride application in middle childhood. A cross-sectional study.童年中期的氟化物应用。一项横断面研究。
Clin Oral Investig. 2025 Aug 7;29(9):398. doi: 10.1007/s00784-025-06477-0.
2
In-vitro-cytotoxicity of cariostatic agents based on fluorides and lanthanide salts in L-929 fibroblasts.基于氟化物和镧系元素盐的抑龋剂对L-929成纤维细胞的体外细胞毒性
Clin Oral Investig. 2025 Jul 2;29(7):366. doi: 10.1007/s00784-025-06429-8.
3
Factors associated with oral health knowledge, attitudes, and practices among legal guardians of preschool children in the Peruvian capital.

本文引用的文献

1
Caries Etiology and Preventive Measures.龋齿病因及预防措施。
Eur J Dent. 2024 Jul;18(3):766-776. doi: 10.1055/s-0043-1777051. Epub 2024 Mar 31.
2
Epidemiological analysis of drinking water-type fluorosis areas and the impact of fluorosis on children's health in the past 40 years in China.中国 40 年来饮水型氟中毒病区及氟中毒对儿童健康影响的流行病学分析。
Environ Geochem Health. 2023 Dec;45(12):9925-9940. doi: 10.1007/s10653-023-01772-9. Epub 2023 Oct 31.
3
Improving Oral Health with Fluoride-Free Calcium-Phosphate-Based Biomimetic Toothpastes: An Update of the Clinical Evidence.
秘鲁首都学龄前儿童法定监护人的口腔健康知识、态度和行为相关因素。
BMC Public Health. 2025 Mar 17;25(1):1030. doi: 10.1186/s12889-025-22099-3.
使用无氟磷酸钙基仿生牙膏改善口腔健康:临床证据更新
Biomimetics (Basel). 2023 Jul 27;8(4):331. doi: 10.3390/biomimetics8040331.
4
Caries-preventing effect of a hydroxyapatite-toothpaste in adults: a 18-month double-blinded randomized clinical trial.羟磷灰石牙膏预防成人龋齿的效果:一项为期 18 个月的双盲随机临床试验。
Front Public Health. 2023 Jul 18;11:1199728. doi: 10.3389/fpubh.2023.1199728. eCollection 2023.
5
On the Application of Calcium Phosphate Micro- and Nanoparticles as Food Additive.磷酸钙微米和纳米颗粒作为食品添加剂的应用
Nanomaterials (Basel). 2022 Nov 19;12(22):4075. doi: 10.3390/nano12224075.
6
Fluoride Exposure from Ready-To-Drink Coffee Consumption.饮用即饮咖啡导致的氟暴露。
Life (Basel). 2022 Oct 16;12(10):1615. doi: 10.3390/life12101615.
7
Fluoride Exposure from Soybean Beverage Consumption: A Toxic Risk Assessment.饮用大豆饮料导致的氟暴露:毒性风险评估
Foods. 2022 Jul 17;11(14):2121. doi: 10.3390/foods11142121.
8
Influence of the Amount of Toothpaste on Cleaning Efficacy: An In Vitro Study.牙膏用量对清洁效果的影响:一项体外研究。
Eur J Dent. 2023 May;17(2):497-503. doi: 10.1055/s-0042-1747953. Epub 2022 Jul 4.
9
Biomimetic hydroxyapatite and caries prevention: a systematic review and meta-analysis.仿生羟磷灰石与龋齿预防:系统评价和荟萃分析。
Can J Dent Hyg. 2021 Oct 1;55(3):148-159. eCollection 2021 Oct.
10
The use of hydroxyapatite toothpaste to prevent dental caries.使用羟基磷灰石牙膏预防龋齿。
Odontology. 2022 Apr;110(2):223-230. doi: 10.1007/s10266-021-00675-4. Epub 2021 Nov 22.