Steringer-Mascherbauer Regina, Huber Charlotte, Fröschl Uwe, Engleder Dagmar, Függer Reinhold, Lummersdorfer Maria, Lenhard Ralf, Martinek Martin
Department of Cardiology, Ordensklinikum Linz GmbH Elisabethinen, 4020 Linz, Austria.
Department of Surgery, Ordensklinikum Linz GmbH Elisabethinen, 4020 Linz, Austria.
J Cardiovasc Dev Dis. 2023 Jul 27;10(8):318. doi: 10.3390/jcdd10080318.
The management of chronic thromboembolic pulmonary hypertension has significantly changed over the last decade with the availability of both specific therapies and interventional treatments. In parallel, implantable pumps for intravenous administration of treprostinil have broadened the spectrum of continuous prostanoid infusion. We evaluated the course of 17 consecutive patients with inoperable chronic thromboembolic pulmonary hypertension treated with treprostinil by means of an implantable infusion pump between 2011 and 2023 at our center. Complications associated with the infusion system were rare, leading to 0.4 unplanned surgical interventions during 17,160 patient days. No additional safety signals were detected, and clinical benefits achieved with subcutaneous treprostinil before pump implantation could be maintained in all patients. No catheter-related infections or thromboembolic events were observed. Implantable infusion pumps offer an attractive alternative to subcutaneous treprostinil for patients intolerant to the subcutaneous route, including those with chronic thromboembolic pulmonary hypertension.
在过去十年中，随着特效疗法和介入治疗的出现，慢性血栓栓塞性肺动脉高压的管理发生了显著变化。与此同时，用于静脉注射曲前列尼尔的植入式泵拓宽了持续前列腺素输注的范围。我们评估了2011年至2023年期间在我们中心连续17例无法手术的慢性血栓栓塞性肺动脉高压患者使用植入式输液泵接受曲前列尼尔治疗的过程。与输液系统相关的并发症很少，在17160个患者日期间导致0.4次非计划性手术干预。未检测到其他安全信号，并且在所有患者中均能维持泵植入前皮下注射曲前列尼尔所取得的临床益处。未观察到与导管相关的感染或血栓栓塞事件。对于不耐受皮下给药途径的患者，包括慢性血栓栓塞性肺动脉高压患者，植入式输液泵为皮下注射曲前列尼尔提供了一种有吸引力的替代方案。
