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心脏组织工程:治疗心力衰竭的一种新兴方法。

Cardiac tissue engineering: an emerging approach to the treatment of heart failure.

作者信息

Rayat Pisheh Hossein, Nojabaei Fatemeh Sadat, Darvishi Ahmad, Rayat Pisheh Ali, Sani Mahsa

机构信息

Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.

Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.

出版信息

Front Bioeng Biotechnol. 2024 Aug 15;12:1441933. doi: 10.3389/fbioe.2024.1441933. eCollection 2024.

Abstract

Heart failure is a major health problem in which the heart is unable to pump enough blood to meet the body's needs. It is a progressive disease that becomes more severe over time and can be caused by a variety of factors, including heart attack, cardiomyopathy and heart valve disease. There are various methods to cure this disease, which has many complications and risks. The advancement of knowledge and technology has proposed new methods for many diseases. One of the promising new treatments for heart failure is tissue engineering. Tissue engineering is a field of research that aims to create living tissues and organs to replace damaged or diseased tissue. The goal of tissue engineering in heart failure is to improve cardiac function and reduce the need for heart transplantation. This can be done using the three important principles of cells, biomaterials and signals to improve function or replace heart tissue. The techniques for using cells and biomaterials such as electrospinning, hydrogel synthesis, decellularization, etc. are diverse. Treating heart failure through tissue engineering is still under development and research, but it is hoped that there will be no transplants or invasive surgeries in the near future. In this study, based on the most important research in recent years, we will examine the power of tissue engineering in the treatment of heart failure.

摘要

心力衰竭是一个重大的健康问题,即心脏无法泵出足够的血液来满足身体的需求。它是一种渐进性疾病,随着时间的推移会变得更加严重,可由多种因素引起,包括心脏病发作、心肌病和心脏瓣膜病。治疗这种疾病有多种方法,其存在许多并发症和风险。知识和技术的进步为许多疾病提出了新方法。心力衰竭一种有前景的新治疗方法是组织工程。组织工程是一个研究领域,旨在创建活组织和器官以替代受损或患病组织。心力衰竭组织工程的目标是改善心脏功能并减少心脏移植的需求。这可以通过细胞、生物材料和信号这三个重要原则来实现,以改善功能或替代心脏组织。使用细胞和生物材料的技术,如静电纺丝、水凝胶合成、去细胞化等多种多样。通过组织工程治疗心力衰竭仍在开发和研究中,但希望在不久的将来无需进行移植或侵入性手术。在本研究中,基于近年来最重要的研究,我们将探讨组织工程在治疗心力衰竭方面的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2355/11357970/4de183707090/fbioe-12-1441933-g001.jpg

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