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用于个性化临时植入物的可生物降解镁合金

Biodegradable Magnesium Alloys for Personalised Temporary Implants.

作者信息

Hendea Radu Emil, Raducanu Doina, Claver Adrián, García José Antonio, Cojocaru Vasile Danut, Nocivin Anna, Stanciu Doina, Serban Nicolae, Ivanescu Steliana, Trisca-Rusu Corneliu, Campian Radu Septimiu

机构信息

Department of Oral Rehabilitation, Faculty of Dental Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania.

Department of Metallic Materials Processing and Ecometallurgy, University Politehnica of Bucharest, 060042 Bucharest, Romania.

出版信息

J Funct Biomater. 2023 Jul 27;14(8):400. doi: 10.3390/jfb14080400.

Abstract

The objective of this experimental work was to examine and characterise the route for obtaining demonstrative temporary biodegradable personalised implants from the Mg alloy Mg-10Zn-0.5Zr-0.8Ca (wt.%). This studied Mg alloy was obtained in its powder state using the mechanical alloying method, with shape and size characteristics suitable for ensuing 3D additive manufacturing using the SLM (selective laser melting) procedure. The SLM procedure was applied to various processing parameters. All obtained samples were characterised microstructurally (using XRD-X-ray diffraction, and SEM-scanning electron microscopy); mechanically, by applying a compression test; and, finally, from a corrosion resistance viewpoint. Using the optimal test processing parameters, a few demonstrative temporary implants of small dimensions were made via the SLM method. Our conclusion is that mechanical alloying combined with SLM processing has good potential to manage 3D additive manufacturing for personalised temporary biodegradable implants of magnesium alloys. The compression tests show results closer to those of human bones compared to other potential metallic alloys. The applied corrosion test shows result comparable with that of the commercial magnesium alloy ZK60.

摘要

本实验工作的目的是研究并表征从Mg-10Zn-0.5Zr-0.8Ca(重量百分比)镁合金获得示范性临时可生物降解个性化植入物的途径。本研究的镁合金采用机械合金化方法以粉末状态获得,其形状和尺寸特征适合随后使用SLM(选择性激光熔化)工艺进行三维增材制造。SLM工艺应用于各种加工参数。所有获得的样品均进行了微观结构表征(使用XRD-X射线衍射和SEM-扫描电子显微镜);通过压缩试验进行力学性能测试;最后,从耐腐蚀性角度进行测试。使用最佳测试加工参数,通过SLM方法制作了一些小尺寸的示范性临时植入物。我们的结论是,机械合金化与SLM加工相结合在管理镁合金个性化临时可生物降解植入物的三维增材制造方面具有良好潜力。与其他潜在金属合金相比,压缩试验结果更接近人体骨骼。所应用的腐蚀试验结果与商用镁合金ZK60相当。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e6b/10455490/22dd0492196f/jfb-14-00400-g001.jpg

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