三齿菌素 B-G，一种来自海洋附生真菌 sp. Z43 的六种新型脂类化合物。
Trichoderols B-G, Six New Lipids from the Marine Algicolous Fungus sp. Z43.
机构信息
Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.
Shandong Saline-Alkaline Land Modern Agriculture Company, Dongying 257345, China.
出版信息
Mar Drugs. 2023 Aug 17;21(8):453. doi: 10.3390/md21080453.
Six new lipids, trichoderols B-G (-), along with a known one, triharzianin B (), were isolated from the culture of sp. Z43 obtained from the surface of the marine brown alga . Their structures and relative configurations were identified by interpretation of 1D/2D NMR and MS data. Compounds - were assayed for inhibiting the growth of three phytopathogenic fungi (, , and ), four marine phytoplankton species (, , , and ), and one marine zooplankton (). Compounds , , and exhibited weak antifungal activities against three phytopathogenic fungi tested with MIC ≥ 64 μg/mL. All compounds displayed moderate antimicroalgal activity with IC ≥ 15 μg/mL and low toxicity to the brine shrimp .
从海洋褐藻表面分离得到的 sp. Z43 的培养物中分离得到了 6 种新的脂质，即 trichoderols B-G(-)，以及一种已知化合物 triharzianin B()。通过解析 1D/2D NMR 和 MS 数据，鉴定了它们的结构和相对构型。测定了化合物 - 对三种植物病原菌（、、和）、四种海洋浮游植物（、、、和）和一种海洋浮游动物（）的生长抑制活性。化合物、和对三种测试的植物病原菌表现出较弱的抗真菌活性，MIC ≥ 64 μg/mL。所有化合物均表现出中等的抗微藻活性，IC ≥ 15 μg/mL，对卤虫的毒性较低。
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