Upadhaya Sweety, Acharya Jyoti, Zolfo Maria, Nair Divya, Kharel Mahesh, Shrestha Anjana, Shrestha Basudha, Madhup Surendra Kumar, Raghubanshi Bijendra Raj, Kattel Hari Prasad, Rajbhandari Piyush, Bhandari Parmananda, Thakur Subhash, Singh Gyani, Shrestha Lilee, Jha Runa
National Public Health Laboratory, Kathmandu 44600, Nepal.
Institute of Tropical Medicine, 2000 Antwerp, Belgium.
Trop Med Infect Dis. 2023 Aug 4;8(8):399. doi: 10.3390/tropicalmed8080399.
An operational research study was conducted in 2019 to assess the quality of data submitted by antimicrobial resistance (AMR) surveillance sites in the Bagmati Province of Nepal to the National Public Health Laboratory for Global Antimicrobial Resistance and Use Surveillance System (GLASS). Measures were implemented to enhance the quality of AMR surveillance by strengthening capacity, improving infrastructure, implementing data sharing guidelines, and supervision. The current study examined reports submitted by surveillance sites in the same province in 2022 to assess whether the data quality had improved since 2019. The availability of infrastructure at the sites was assessed. Of the nine surveillance sites in the province, seven submitted reports in 2022 versus five in 2019. Completeness in reporting improved significantly from 19% in 2019 to 100% in 2022 ( < 0.001). Timely reports were received from two sites in 2019 and only one site in 2022. Specimen-pathogen consistency in accordance with the GLASS guidelines for urine, feces, and genital swab specimens improved, with ≥90% consistency at all sites. Overall, the pathogen-antibacterial consistency improved significantly for each GLASS priority pathogen. The study highlights the importance of dedicated infrastructure and institutional arrangements for AMR surveillance. Similar assessments covering all provinces of the country can provide a more complete country-wide picture.
2019年开展了一项运筹学研究，以评估尼泊尔巴格马蒂省抗菌药物耐药性（AMR）监测点向国家公共卫生实验室提交的用于全球抗菌药物耐药性与使用监测系统（GLASS）的数据质量。通过加强能力建设、改善基础设施、实施数据共享指南以及监督等措施来提高AMR监测的质量。本研究调查了该省监测点在2022年提交的报告，以评估自2019年以来数据质量是否有所提高。对各监测点的基础设施可用性进行了评估。该省的9个监测点中，2022年有7个提交了报告，而2019年为5个。报告的完整性从2019年的19%显著提高到2022年的100%（<0.001）。2019年从2个监测点收到了及时报告，2022年只有1个监测点。根据GLASS关于尿液、粪便和生殖器拭子标本的指南，标本与病原体的一致性有所提高，所有监测点的一致性均≥90%。总体而言，每种GLASS重点病原体的病原体与抗菌药物的一致性都有显著提高。该研究强调了AMR监测专用基础设施和制度安排的重要性。涵盖该国所有省份的类似评估可以提供更全面的全国情况。
