Department of Rheumatology and Musculoskeletal Medicine, Yoshii Hospital, 6-7-5 Nakamura-Ohashidori, Shimanto, Kochi, 787-0033, Japan.
Department of Rheumatology, Kochi Memorial Hospital, 4-13 Shiromi-Cho, Kochi, Kochi, 780-0824, Japan.
Sci Rep. 2023 Aug 25;13(1):13908. doi: 10.1038/s41598-023-39711-4.
Clinical importance of time length from initiation under treat-to-target (T2T) strategy to acquisition of clinical remission (TL) in treating patients with rheumatoid arthritis (RA) on disease activity control, daily activities, and quality of life maintenance was investigated. In patients who achieved Boolean remission once or more, relationship between TL and patients' background data at initiation, and relationship between TL and mean simplified disease activity score (SDAI), Health Assessment Questionnaire Disability Index (HAQ-DI) score, pain score with visual analog scale (PS-VAS), Sharp/van der Heijde Score (SHS) and quality of life score (QOLS) at the first remission and thereafter were evaluated statistically. Patients were divided into two groups whether TL was within 6 months or longer (G ≤ 6 and G > 6). Change of the parameters and Boolean remission rate (BRR) after the first remission between the two groups were compared statistically. In 465 patients, TL correlated significantly with the SDAI score, the HAQ score, PS-VAS, SHS, and the QOLS after the remission. The SDAI score and the BRR after the remission were significantly better in the G ≤ 6 than in the G > 6. TL is an important key to guarantee good and stable clinical course in treating under T2T.
研究了从达标治疗（T2T）策略开始到获得临床缓解（TL）的时间长度对类风湿关节炎（RA）患者疾病活动控制、日常活动和生活质量维持的临床重要性。在曾经达到过或多次达到布尔缓解的患者中，TL 与起始时患者背景数据之间的关系，以及 TL 与首次缓解时及之后的简化疾病活动评分（SDAI）均值、健康评估问卷残疾指数（HAQ-DI）评分、视觉模拟评分法疼痛评分（PS-VAS）、Sharp/van der Heijde 评分（SHS）和生活质量评分（QOLS）之间的关系进行了统计学评估。患者根据 TL 是否在 6 个月内（G≤6 和 G＞6）分为两组。比较两组之间首次缓解后参数变化和布尔缓解率（BRR）。在 465 例患者中，TL 与缓解后的 SDAI 评分、HAQ 评分、PS-VAS、SHS 和 QOLS 显著相关。缓解后的 SDAI 评分和 BRR 在 G≤6 组中显著优于 G＞6 组。TL 是保证 T2T 治疗下良好且稳定临床病程的重要关键。
