Chen Jun, Zhong Haopeng, Huang Zhouyin, Chen Xingping, You Jinming, Zou Tiande
Jiangxi Province Key Laboratory of Animal Nutrition, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China.
Antioxidants (Basel). 2023 Aug 20;12(8):1642. doi: 10.3390/antiox12081642.
Kaempferol, a secondary metabolite found in plants, is a naturally occurring flavonoid displaying significant potential in various biological activities. The chemical structure of kaempferol is distinguished by the presence of phenyl rings and four hydroxyl substituents, which make it an exceptional radical scavenger. Most recently, an increasing number of studies have demonstrated the significance of kaempferol in the regulation of intestinal function and the mitigation of intestinal inflammation. The focus of the review will primarily be on its impact in terms of antioxidant properties, inflammation, maintenance of intestinal barrier function, and its potential in the treatment of colorectal cancer and obesity. Future research endeavors should additionally give priority to investigating the specific dosage and duration of kaempferol administration for different pathological conditions, while simultaneously conducting deeper investigations into the comprehensible mechanisms of action related to the regulation of aryl hydrocarbon receptor (AhR). This review intends to present novel evidence supporting the utilization of kaempferol in the regulation of gut health and the management of associated diseases.
山奈酚是一种存在于植物中的次生代谢产物，是一种天然存在的黄酮类化合物，在各种生物活性中显示出巨大潜力。山奈酚的化学结构以苯环和四个羟基取代基的存在为特征，这使其成为一种特殊的自由基清除剂。最近，越来越多的研究表明山奈酚在调节肠道功能和减轻肠道炎症方面具有重要意义。本综述的重点将主要集中在其抗氧化特性、炎症、维持肠道屏障功能方面的影响，以及其在治疗结直肠癌和肥胖症方面的潜力。未来的研究工作还应优先研究山奈酚在不同病理条件下的具体给药剂量和持续时间，同时深入研究与芳烃受体（AhR）调节相关的可理解的作用机制。本综述旨在提供新的证据，支持山奈酚在调节肠道健康和管理相关疾病中的应用。
