Kim Moon Seong, Kim Jin Man, Lee Sang Gyeong, Jung Eun Jin, Lee Sang Hoon, Huang Wen Yan, Han Bok Kyung, Jung Da Eun, Yang Sung Bum, Ji Inbae, Kim Young Jun, Hong Ji Youn
Department of Food and Regulatory Science, Korea University, Sejong 30019, Republic of Korea.
Department of Food and Biotechnology, Korea University, Sejong 30019, Republic of Korea.
Healthcare (Basel). 2023 Aug 21;11(16):2365. doi: 10.3390/healthcare11162365.
Cardiovascular disease (CVD) is the primary cause of mortality worldwide and imposes a significant social burden on many countries.
This study assessed the health and economic benefits of omega-3 associated with CVD. The meta-analysis estimated the risk ratio (RR) and absolute risk reduction (ARR), and the economic impact was calculated using direct and indirect costs related to CVD treatments in Korean adults.
A total of 33 studies were included in the meta-analysis on CVD outcomes, with 80,426 participants in the intervention group and 80,251 participants in the control group. The meta-analysis determined a significant reduction in omega-3 in CVD (RR = 0.92, 95% CI: 0.86~0.97) and ARR (1.48%). Additionally, the subgroup analysis indicated that higher doses and the long-term consumption of omega-3 could further enhance these effects. After applying ARR from meta-analysis to the target population of about 1,167,370 in 2021, the Republic of Korea, it was estimated that omega-3 consumption could result in an economic benefit of KRW 300 billion by subtracting the purchase expenses of omega-3 supplements from the total social cost savings.
Omega-3 supplements can help to reduce the risk of CVD and subsequent economic benefits in the Republic of Korea.
心血管疾病（CVD）是全球主要的死亡原因，给许多国家带来了巨大的社会负担。
本研究评估了ω-3与心血管疾病相关的健康和经济效益。荟萃分析估计了风险比（RR）和绝对风险降低率（ARR），并使用韩国成年人心血管疾病治疗的直接和间接成本计算了经济影响。
共有33项研究纳入了关于心血管疾病结局的荟萃分析，干预组有80426名参与者，对照组有80251名参与者。荟萃分析确定ω-3可显著降低心血管疾病风险（RR = 0.92，95%CI：0.86~0.97）和绝对风险降低率（1.48%）。此外，亚组分析表明，更高剂量和长期食用ω-3可进一步增强这些效果。将荟萃分析中的绝对风险降低率应用于2021年韩国约1167370人的目标人群后，估计食用ω-3可通过从社会总成本节省中减去ω-3补充剂的购买费用，带来3000亿韩元的经济效益。
在韩国，ω-3补充剂有助于降低心血管疾病风险并带来后续经济效益。
