Raccagni Angelo Roberto, Gianotti Nicola, Moro Matteo, Mileto Davide, Gordo Perez Victoria, Castagna Antonella, Nozza Silvia
Infectious Diseases Unit, Vita-Salute San Raffaele University, 20132 Milan, Italy.
Infectious Diseases Unit, San Raffaele Scientific Institute, 20132 Milan, Italy.
Life (Basel). 2023 Aug 8;13(8):1705. doi: 10.3390/life13081705.
Mpox has caused a global outbreak since May 2022, particularly affecting people belonging to key populations, but cases among healthcare providers have been reported. The aim of this work is to present the experience of the Infectious Diseases Unit of San Raffaele Scientific Institute, Milan, Italy with respect to infection control and prevention of mpox occupational transmission. Between May-November 2022, 140 individuals were diagnosed with mpox and six required hospitalization. Overall, 12 medical doctors and 22 nurses provided care to people with mpox. A hospital policy aimed at controlling viral transmission was implemented in May 2022. Protective equipment was used for all healthcare providers. One accidental puncture occurred with a scalpel contaminated with blood from a mpox viremic individual (mpox plasma cycle threshold = 36); no mpox related symptoms were observed and mpox testing ruled out transmission. Six months following exposure, neutralizing antibodies were not detectable, ruling out contagion. Overall, we observed no mpox transmission among healthcare workers, despite the number of visits and procedures performed, including bodily-fluids sampling, and even following puncture with contaminated blood. Hospital preparedness for the management of new infectious disease outbreaks, with rapid implementation of policies aimed at controlling infection, is paramount to avoid occupational transmission.
自2022年5月以来，猴痘已引发全球疫情，尤其影响到关键人群，但也有医疗保健人员感染病例的报告。本文旨在介绍意大利米兰圣拉斐尔科学研究所传染病科在感染控制和预防猴痘职业传播方面的经验。2022年5月至11月期间，140人被诊断感染猴痘，其中6人需要住院治疗。总体而言，12名医生和22名护士为猴痘患者提供了护理。2022年5月实施了一项旨在控制病毒传播的医院政策。所有医护人员均使用了防护设备。有一次，一名医护人员被一名猴痘病毒血症患者的血液污染的手术刀意外刺伤（猴痘血浆循环阈值 = 36）；未观察到与猴痘相关的症状，猴痘检测排除了传播。暴露六个月后，未检测到中和抗体，排除了感染。总体而言，尽管进行了多次探视和操作，包括采集体液样本，甚至在被污染血液刺伤后，我们并未观察到医护人员之间发生猴痘传播。医院对新传染病疫情的管理准备，以及迅速实施旨在控制感染的政策，对于避免职业传播至关重要。
