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肉毒杆菌毒素在半面痉挛中的临床应用

Clinical Application of Botulinum Toxin for Hemifacial Spasm.

作者信息

Park Chang-Kyu, Lim Seung-Hoon, Park Kwan

机构信息

Department of Neurosurgery, Kyung Hee University College of Medicine, Seoul 02447, Republic of Korea.

Department of Neurosurgery, Konkuk University Medical Center, Seoul 05030, Republic of Korea.

出版信息

Life (Basel). 2023 Aug 17;13(8):1760. doi: 10.3390/life13081760.

DOI:10.3390/life13081760
PMID:37629617
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10455826/
Abstract

Hemifacial spasm is typically caused by contact between the facial nerve and blood vessels. Microvascular decompression, a treatment that directly addresses this pathogenesis, is often considered the most effective treatment method. However, surgery is not immediately performed for patients at risk from the surgical treatment, or for those with an unclear diagnosis. In these instances, Botulinum toxin injection can help manage the patient's symptoms. Numerous studies corroborate the effectiveness and safety of Botulinum toxin treatment, with large-scale studies indicating symptom control lasts, on average, around 15 weeks.

摘要

面肌痉挛通常由面神经与血管之间的接触引起。微血管减压术是一种直接针对这种发病机制的治疗方法,常被认为是最有效的治疗方式。然而,对于有手术治疗风险的患者或诊断不明确的患者,不会立即进行手术。在这些情况下,肉毒杆菌毒素注射有助于控制患者的症状。大量研究证实了肉毒杆菌毒素治疗的有效性和安全性,大规模研究表明症状控制平均持续约15周。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1321/10455826/8a2044afc6de/life-13-01760-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1321/10455826/8a2044afc6de/life-13-01760-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1321/10455826/8a2044afc6de/life-13-01760-g001.jpg

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A Double-Blind, Placebo-Controlled Study of Appropriate Site of Botulinum Toxin Therapy in Hemifacial Spasm.一项关于肉毒杆菌毒素治疗半面痉挛合适部位的双盲、安慰剂对照研究。
Adv Ther. 2022 May;39(5):2025-2034. doi: 10.1007/s12325-022-02077-6. Epub 2022 Mar 10.
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[Therapy of Hemifacial Spasm with Botulinum Toxin: an Update].[肉毒杆菌毒素治疗面肌痉挛:最新进展]
Fortschr Neurol Psychiatr. 2022 Jan;90(1-02):37-41. doi: 10.1055/a-1677-4008. Epub 2022 Jan 12.
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Botulinum Toxin for the Treatment of Hemifacial Spasm: An Update on Clinical Studies.
肉毒杆菌毒素治疗面肌痉挛:协调神经学和美学效果。
J Neural Transm (Vienna). 2025 Jan;132(1):23-38. doi: 10.1007/s00702-024-02821-y. Epub 2024 Aug 23.
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Toxins (Basel). 2021 Dec 9;13(12):881. doi: 10.3390/toxins13120881.
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Real-world experience with botulinum toxin A for the treatment of hemifacial spasm: A study of 1138 injections.肉毒杆菌毒素A治疗面肌痉挛的真实世界经验:一项关于1138次注射的研究。
Clin Neurol Neurosurg. 2021 Jun;205:106632. doi: 10.1016/j.clineuro.2021.106632. Epub 2021 Apr 2.
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