Radoi Cristiana Luiza, Zlatian Ovidiu Mircea, Balasoiu Maria, Giubelan Lucian, Stoian Andreea Cristina, Dragonu Livia, Neacsu Alexandru, Iliescu Dominic Gabriel
Doctoral School, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Medical Laboratory, County Clinical Emergency Hospital of Craiova, 200349 Craiova, Romania.
Microorganisms. 2023 Aug 10;11(8):2057. doi: 10.3390/microorganisms11082057.
Toxoplasmosis, caused by the obligate intracellular protozoan parasite Toxoplasma gondii (), is a globally prevalent zoonotic disease with potentially severe implications for immunocompromised individuals, pregnant women, and their fetuses/children. This study examined the prevalence of anti- IgM and IgG antibodies in two groups of childbearing age women, including 653 participants in Group 1 (2013-2016) and 3221 participants in Group 2 (2019-2022). Our results revealed a decrease in the overall positivity rate of anti- IgM antibodies from 2.32% to 1.06%, suggesting improved public health interventions over time. However, there were variations among different age groups and between rural and urban environments, with a significant decrease in urban areas across all age groups from Group 1 to Group 2. Regarding anti- IgG antibodies, we did not observe a significant change in the seropositivity rate between the two groups. In the rural population with an age group over 35 years, we observed the highest positivity rate in Group 2. This study provided information on the risk factors and burden of toxoplasmosis in women of childbearing age with data that can be valuable to public health policies and the planning of healthcare measures for effective toxoplasmosis management.
弓形虫病由专性细胞内原生动物寄生虫刚地弓形虫引起，是一种全球流行的人畜共患病，对免疫功能低下的个体、孕妇及其胎儿/儿童可能产生严重影响。本研究调查了两组育龄妇女中抗IgM和IgG抗体的流行情况，其中第1组有653名参与者（2013 - 2016年），第2组有3221名参与者（2019 - 2022年）。我们的结果显示，抗IgM抗体的总体阳性率从2.32%降至1.06%，表明随着时间推移公共卫生干预有所改善。然而，不同年龄组以及农村和城市环境之间存在差异，从第1组到第2组，所有年龄组的城市地区均有显著下降。关于抗IgG抗体，我们未观察到两组之间血清阳性率有显著变化。在35岁以上年龄组的农村人口中，我们观察到第2组的阳性率最高。本研究提供了育龄妇女弓形虫病的风险因素和负担信息，这些数据对于公共卫生政策以及有效管理弓形虫病的医疗措施规划具有重要价值。
