Bieńkowski Carlo, Aniszewska Małgorzata, Kowalczyk Monika, Popielska Jolanta, Zawadka Konrad, Ołdakowska Agnieszka, Pokorska-Śpiewak Maria
Doctoral School, Medical University of Warsaw, Żwirki i Wigury 61, 02-091 Warsaw, Poland.
Department of Children's Infectious Diseases, Medical University of Warsaw, Wolska 37, 02-091 Warsaw, Poland.
J Clin Med. 2022 Feb 19;11(4):1105. doi: 10.3390/jcm11041105.
(TG) is a parasitic protozoon that may cause miscarriages or birth defects if the infection occurs during pregnancy. The study's aim was to evaluate the risk factors associated with TG infection in pregnant women.
Medical charts for all 273 pregnant women with suspected TG infection consecutively admitted to the Hospital of Warsaw between 2019 and 2020 were retrospectively analyzed. The presumptive TG diagnosis was verified by a serologic assessment of IgM and IgG titers, and IgG affinity tests.
The median age was 32 years (range: 19-42 years). The diagnosis of primary TG infection was confirmed in 74/273 (27.1%) women. In 114/273 (41.8%) there was evidence of past infection. In 71/273 (26%) women, an infection was excluded. In 172/273 (62%) women the recommended testing for other infectious diseases putting fetus development at risk was performed correctly. Logistic regression model analysis revealed that living in rural areas and eating raw meat were independent factors associated with increased risk of TG infection during pregnancy (OR 2.89, 95% CI: 1.42-5.9, = 0.004; and OR 2.07, 95% CI: 1.03-4.18, = 0.04, respectively).
The independent risk factors for TG infection during pregnancy include living in rural areas and eating raw meat. The physician's educational role here is crucial for the efficient prevention of congenital toxoplasmosis.
弓形虫（TG）是一种寄生原生动物，如果在孕期发生感染，可能会导致流产或出生缺陷。本研究的目的是评估与孕妇弓形虫感染相关的风险因素。
回顾性分析了2019年至2020年期间连续入住华沙医院的273名疑似弓形虫感染孕妇的病历。通过对IgM和IgG滴度进行血清学评估以及IgG亲和力测试来验证弓形虫的初步诊断。
中位年龄为32岁（范围：19 - 42岁）。74/273（27.1%）名女性被确诊为原发性弓形虫感染。114/273（41.8%）名女性有既往感染的证据。71/273（26%）名女性被排除感染。172/273（62%）名女性正确进行了针对其他可能危及胎儿发育的传染病的推荐检测。逻辑回归模型分析显示，生活在农村地区和食用生肉是与孕期弓形虫感染风险增加相关的独立因素（比值比分别为2.89，95%置信区间：1.42 - 5.9，P = 0.004；以及比值比2.07，95%置信区间：1.03 - 4.18，P = 0.04）。
孕期弓形虫感染的独立风险因素包括生活在农村地区和食用生肉。医生在此的教育作用对于有效预防先天性弓形虫病至关重要。
