Department of Pharmacology, Pediatrics and Organic Chemistry, Faculty of Pharmacy, Miguel Hernández University (UMH), 03202 Elche, Spain.
Department R&D MATCH Biosystems, S.L. Edificio Quórum IV, Miguel Hernandez University Science Park, Avd. de la Universidad s/n, 03202 Elche, Spain.
Nutrients. 2023 Aug 11;15(16):3551. doi: 10.3390/nu15163551.
Depressive disorders have a major impact on occupational health and are costly to the economy and the healthcare system. Probiotics are live, non-pathogenic micro-organisms that, when ingested in adequate amounts, can colonize the intestinal tract and confer health benefits on the patient. In recent years, numerous studies have described the potential usefulness of certain probiotic strains in the treatment and prevention of depressive disorders, with differing results. In order to evaluate the possible efficacy and safety of these microorganisms in preventing or ameliorating these disorders, we systematically searched the bibliographic databases MEDLINE (via Pubmed), EMBASE, the Cochrane library, Scopus and Web of science, using the descriptors "Occupational health", "Probiotics", "Depressive Disorder" and "Depression" and filters "Humans" and "Clinical Trials". After applying our inclusion and exclusion criteria, 18 studies were accepted for review and critical analysis. Our analysis suggests that a combination of different probiotic strains, most of them from the genus sp. and sp., could be a good mixture as an adjuvant in the treatment of depressive disorders for the working population.
抑郁障碍对职业健康有重大影响，给经济和医疗保健系统造成巨大负担。益生菌是活的、非病原性微生物，当摄入足够量时，可以在肠道定殖，并使患者受益。近年来，许多研究描述了某些益生菌菌株在治疗和预防抑郁障碍方面的潜在作用，但结果不一。为了评估这些微生物预防或改善这些疾病的可能疗效和安全性，我们系统地检索了 MEDLINE（通过 Pubmed）、EMBASE、Cochrane 图书馆、Scopus 和 Web of science 等文献数据库，使用了“职业健康”、“益生菌”、“抑郁障碍”和“抑郁”等描述词，并使用了“人类”和“临床试验”过滤器。在应用我们的纳入和排除标准后，接受了 18 项研究进行审查和批判性分析。我们的分析表明，不同益生菌菌株的组合，其中大多数来自属 sp. 和 sp.，可能是治疗工作人群抑郁障碍的一种很好的辅助治疗方法。
