Aldawsari Mohammed F, Alkholifi Faisal K, Foudah Ahmed I, Alqarni Mohammed H, Alam Aftab, Salkini Mohamad Ayman, Sweilam Sherouk Hussein
Department of Pharmaceutics, College of Pharmacy, Prince Sattam bin Abdulaziz University, Al Kharj 11942, Saudi Arabia.
Department of Pharmacology & Toxicology, College of Pharmacy, Prince Sattam bin Abdulaziz University, Al Kharj 11942, Saudi Arabia.
Pharmaceuticals (Basel). 2023 Jul 31;16(8):1090. doi: 10.3390/ph16081090.
The objective of this study was to develop an innovative gallic-acid (GA) drug delivery system that could be administered transdermally, resulting in enhanced therapeutic benefits and minimal negative consequences. The method employed involved the preparation of poly(lactic-co-glycolic acid) (PLGA) nanoparticles loaded with GA through nanoprecipitation-denoted GA@PLGANPs. The results reveal that this strategy led to perfectly spherical, homogeneous, and negatively charged particles, which are suitable for administration via skin patches or ointments. A further analysis indicates that these GA@PLGANPs exhibit remarkable antioxidant activity as well as potent antibacterial effects against a diverse range of microorganisms, making them ideal candidates for numerous applications. Additionally, it has been observed that these nanoparticles can effectively mitigate oxidative stress while also significantly inhibiting microbial growth by exerting detrimental effects on bacterial cell walls or membranes. In conclusion, on the basis of the findings presented in this study, there is strong evidence supporting the potential use of GA@PLGANPs as an effective therapy option with reduced side effects compared to conventional drug delivery methods.
本研究的目的是开发一种创新的没食子酸（GA）药物递送系统，该系统可经皮给药，从而提高治疗效果并将负面影响降至最低。所采用的方法包括通过纳米沉淀法制备负载GA的聚乳酸-乙醇酸共聚物（PLGA）纳米颗粒，即GA@PLGANPs。结果表明，该策略产生了完美球形、均匀且带负电荷的颗粒，适用于通过皮肤贴片或软膏给药。进一步分析表明，这些GA@PLGANPs具有显著的抗氧化活性以及对多种微生物的强效抗菌作用，使其成为众多应用的理想候选物。此外，据观察，这些纳米颗粒可有效减轻氧化应激，同时通过对细菌细胞壁或细胞膜产生有害影响来显著抑制微生物生长。总之，基于本研究提出的结果，有强有力的证据支持GA@PLGANPs作为一种有效的治疗选择的潜在用途，与传统药物递送方法相比，其副作用更少。
