Harwansh Ranjit K, Deshmukh Rohitas, Shukla Vijay Pratap, Khunt Dignesh, Prajapati Bhupendra Gopalbhai, Rashid Summya, Ali Nemat, Elossaily Gehan M, Suryawanshi Vijendra Kumar, Kumar Arun
Institute of Pharmaceutical Research, GLA University, Mathura 281406, India.
School of Pharmacy, Gujarat Technological University, Gandhinagar 382027, India.
Pharmaceutics. 2024 Sep 13;16(9):1202. doi: 10.3390/pharmaceutics16091202.
Gallic acid (GA) is a well-known herbal bioactive compound found in many herbs and foods like tea, wine, cashew nuts, hazelnuts, walnuts, plums, grapes, mangoes, blackberries, blueberries, and strawberries. GA has been reported for several pharmacological activities, such as antioxidant, inflammatory, antineoplastic, antimicrobial, etc. Apart from its incredible therapeutic benefits, it has been associated with low permeability and bioavailability issues, limiting their efficacy. GA belongs to BCS (Biopharmaceutics classification system) class III (high solubility and low probability). In this context, novel drug delivery approaches played a vital role in resolving these GA issues. Nanocarrier systems help improve drug moiety's physical and chemical stability by encapsulating them into a lipidic or polymeric matrix or core system. In this regard, researchers have developed a wide range of nanocarrier systems for GA, including liposomes, transfersomes, niosomes, dendrimers, phytosomes, micelles, nanoemulsions, metallic nanoparticles, solid lipid nanoparticles (SLNs), nanoparticles, nanostructured lipid carriers, polymer conjugates, etc. In the present review, different search engines like Scopus, PubMed, ScienceDirect, and Google Scholar have been referred to for acquiring recent information on the theme of the work. Therefore, this review paper aims to emphasize several novel drug delivery systems, patents, and clinical updates of GA.
没食子酸（GA）是一种广为人知的草本生物活性化合物，存在于许多草药和食物中，如茶叶、葡萄酒、腰果、榛子、核桃、李子、葡萄、芒果、黑莓、蓝莓和草莓。GA已被报道具有多种药理活性，如抗氧化、抗炎、抗肿瘤、抗菌等。除了其令人难以置信的治疗益处外，它还存在低渗透性和生物利用度问题，限制了其疗效。GA属于BCS（生物药剂学分类系统）III类（高溶解性和低渗透性）。在这种情况下，新型药物递送方法在解决这些GA问题方面发挥了至关重要的作用。纳米载体系统通过将药物部分包裹在脂质或聚合物基质或核心系统中来帮助提高其物理和化学稳定性。在这方面，研究人员已经为GA开发了各种各样的纳米载体系统，包括脂质体、传递体、非离子表面活性剂囊泡、树枝状大分子、植物脂质体、胶束、纳米乳剂、金属纳米颗粒、固体脂质纳米颗粒（SLN）、纳米颗粒、纳米结构脂质载体、聚合物缀合物等。在本综述中，参考了不同的搜索引擎，如Scopus、PubMed、ScienceDirect和谷歌学术，以获取有关该工作主题的最新信息。因此，这篇综述文章旨在强调GA的几种新型药物递送系统、专利和临床进展。
