Abdel-Galil A M
Oncology. 1986;43(5):335-7. doi: 10.1159/000226394.
The effect of vitamin C (L-ascorbic acid) on methylcholanthrene (MCA)-induced local malignant sarcomas in mice was investigated. Four groups of mice were given single intramuscular application of MCA at a dose level of 0.5 mg/0.1 ml olive oil for each animal. Doses of 6, 25, and 35 mg vitamin C (VC)/mouse were given to animals of groups B, C and D, respectively. VC was applied in drinking water by intragastric administration 5 times weekly for the first 20 weeks. Animals of group A served as carcinogenic controls. The application of VC statistically prevented the induction of sarcomas in mice of groups B, C and D compared to carcinogenic controls (group A). VC supplementation did not significantly reduce the diameters and weights of tumors. It was concluded that, under the experimental conditions conducted, VC significantly prevented the induction of sarcomas in mice providing a good prophylactic activity; however, it did not achieve a significant therapeutic level.
研究了维生素C（L-抗坏血酸）对甲基胆蒽（MCA）诱导的小鼠局部恶性肉瘤的影响。将四组小鼠每只动物以0.5mg/0.1ml橄榄油的剂量水平进行单次肌肉注射MCA。分别给B、C和D组动物给予6、25和35mg维生素C（VC）/小鼠的剂量。在最初的20周内，每周通过胃内给药5次将VC应用于饮用水中。A组动物作为致癌对照组。与致癌对照组（A组）相比，VC的应用在统计学上阻止了B、C和D组小鼠肉瘤的诱导。补充VC并没有显著减小肿瘤的直径和重量。得出的结论是，在进行的实验条件下，VC显著阻止了小鼠肉瘤的诱导，具有良好的预防活性；然而，它没有达到显著的治疗水平。
