Trukhanova L S, Parfenov Iu D, Turusov V S
Vopr Onkol. 1990;36(5):563-7.
The administration of estradiol propionate after the discontinuation of 1,2-dimethylhydrazine (DMH) treatment increased the incidence of uterine sarcoma in CBA mice from 32.5 (DMH alone) to 62.5%. The addition of the ascorbic acid (0.3% solution in drinking water) to estradiol propionate was followed by a decrease in the tumor incidence to 35%, i. e. the acid levelled the promoting effect of estradiol propionate almost completely. Sodium ascorbate did not share that effect. Mechanisms underlying the antiestrogenic effect of the ascorbic acid are discussed.
在停止1,2 - 二甲基肼（DMH）治疗后给予丙酸雌二醇，使CBA小鼠子宫肉瘤的发生率从32.5%（仅DMH处理）增加到62.5%。在丙酸雌二醇中添加抗坏血酸（饮用水中0.3%的溶液）后，肿瘤发生率降至35%，即该酸几乎完全消除了丙酸雌二醇的促进作用。抗坏血酸钠没有这种作用。文中讨论了抗坏血酸抗雌激素作用的潜在机制。
