Chen Chan, Roy Shubham, Wang Jingjing, Lu Xiafen, Li Siyi, Yang Hao, Cheng Minggang, Guo Bing, Xu Yuzhong
Department of Clinical Laboratory, Shenzhen Baoan Hospital, The Second Affiliated Hospital of Shenzhen University, Shenzhen 518000, China.
School of Science, Shenzhen Key Laboratory of Advanced Functional Carbon Materials Research and Comprehensive Application, Harbin Institute of Technology, Shenzhen 518055, China.
Pharmaceutics. 2023 Aug 17;15(8):2155. doi: 10.3390/pharmaceutics15082155.
Nowadays, bacterial infection is regarded as a serious threat to humankind, which needs to be taken care of. The emergence of antibiotic resistance and multidrug resistance (MDR) is rendering this situation more troublesome. However, several alternative treatment regimens have aided such diseases quite well in the recent past, among which dynamic antibacterial therapies combat this situation quite well. Among various dynamic therapies, piezodynamic therapy is a very recent avenue, in which mechanical stimuli have been exploited to treat bacterial infections. Herein, piezo-active bismuth ferrite-loaded poly(vinylidene fluoride-co-hexafluoropropylene) polymer has been utilized to eradicate gram-positive bacteria () and gram-negative bacteria (). The sample has been designed in a free-standing membrane form, which, under soft ultrasound (~10 kHz), generates reactive radicals to ablate bacteria. Initially, the structure and morphology of the membrane have been substantiated by using X-ray diffraction and scanning electron microscopy methods; besides, Fourier transform infrared spectrum of the sample depicts a tremendously high value of polarizability and further confirms the piezo-activity of the membrane. More than 99% of and have been successfully eradicated within 30 min of ultrasound. Moreover, the solid-state structure and hydrophobic nature of the membrane help us to reuse it in a cyclic manner, which is possibly reported herein for the very first time. This novel membrane could be deployed in healthcare systems and pigment industries and could be exploited as a self-cleaning material.
如今，细菌感染被视为对人类的严重威胁，需要加以关注。抗生素耐药性和多重耐药性（MDR）的出现使这种情况变得更加棘手。然而，最近一些替代治疗方案对这类疾病起到了很好的辅助作用，其中动态抗菌疗法能很好地应对这种情况。在各种动态疗法中，压电动力疗法是一个非常新的途径，它利用机械刺激来治疗细菌感染。在此，负载压电活性铋铁氧体的聚（偏二氟乙烯 - 共 - 六氟丙烯）聚合物已被用于根除革兰氏阳性菌（）和革兰氏阴性菌（）。该样品被设计成独立膜形式，在软超声（约10 kHz）作用下会产生活性自由基以杀灭细菌。首先，通过X射线衍射和扫描电子显微镜方法证实了膜的结构和形态；此外，样品的傅里叶变换红外光谱显示出极高的极化率值，并进一步证实了膜的压电活性。在超声作用30分钟内，超过99%的和已被成功根除。此外，膜的固态结构和疏水性质有助于我们以循环方式重复使用它，这可能是本文首次报道。这种新型膜可应用于医疗保健系统和颜料工业，并可作为自清洁材料加以利用。
