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负载顺铂的明胶功能化碳纳米管用于抗癌治疗

Gelatin-Functionalized Carbon Nanotubes Loaded with Cisplatin for Anti-Cancer Therapy.

作者信息

Li Rong, Bao Zhenfei, Wang Pei, Deng Yunyun, Fan Junping, Zhu Xin, Xia Xinyu, Song Yiming, Yao Haiyan, Li Dongfang

机构信息

School of Stomatology, Nanchang University, Nanchang 330006, China.

The Key Laboratory of Oral Biomedicine, Jiangxi Province, Nanchang 330006, China.

出版信息

Polymers (Basel). 2023 Aug 8;15(16):3333. doi: 10.3390/polym15163333.

DOI:10.3390/polym15163333
PMID:37631391
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10458187/
Abstract

Cisplatin (Cp), a chemotherapeutic agent, interacts with purines on tumor DNA, causing tumor cell apoptosis. However, cisplatin has the characteristics of non-specific distribution and lack of selectivity, resulting in systemic toxicity. Moreover, it cannot maintain the drug's high concentration in the tumor-weak acid environment. These flaws of cisplatin restrict its use in clinical applications. Therefore, a pH-responsive carbon nanotube-modified nano-drug delivery system (CNTs/Gel/Cp) was constructed in this study using gelatin (Gel)-modified carbon nanotubes (CNTs/Gel) loaded with cisplatin to release drugs precisely and slowly, preventing premature inactivation and maintaining an effective concentration. When M:M = 1:1, the drug reaches the highest loading rate and entrapment efficiency. To achieve the sustained-release effect, CNTs/Gel/Cp can release the medicine steadily for a long time in a pH environment of 6.0. Additionally, CNTs/Gel/Cp display antitumor properties comparable to cisplatin in a manner that varies with the dosage administered. These findings indicate that CNTs/Gel/Cp have an effective, sustained release of cisplatin and a good antitumor effect, providing a theoretical and experimental basis for the clinical application of modified carbon nanotubes (CNTs) as a new drug delivery system.

摘要

顺铂（Cp）作为一种化疗药物，可与肿瘤DNA上的嘌呤相互作用，导致肿瘤细胞凋亡。然而，顺铂具有非特异性分布和缺乏选择性的特点，会引发全身毒性。此外，在肿瘤弱酸环境中它无法维持药物的高浓度。顺铂的这些缺陷限制了其在临床应用中的使用。因此，本研究构建了一种pH响应性碳纳米管修饰的纳米药物递送系统（CNTs/Gel/Cp），该系统使用负载顺铂的明胶（Gel）修饰碳纳米管（CNTs/Gel）来精确缓慢地释放药物，防止药物过早失活并维持有效浓度。当M:M = 1:1时，药物达到最高载药率和包封率。为实现缓释效果，CNTs/Gel/Cp在pH为6.0的环境中可长时间稳定释放药物。此外，CNTs/Gel/Cp以随给药剂量变化的方式展现出与顺铂相当的抗肿瘤特性。这些研究结果表明，CNTs/Gel/Cp具有有效、持续释放顺铂以及良好的抗肿瘤效果，为修饰碳纳米管（CNTs）作为新型药物递送系统的临床应用提供了理论和实验依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd01/10458187/643f95d775f6/polymers-15-03333-g014.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd01/10458187/f8d4827a22a1/polymers-15-03333-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd01/10458187/c4bc97227027/polymers-15-03333-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd01/10458187/652172d44afc/polymers-15-03333-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd01/10458187/74263b122ebf/polymers-15-03333-g011.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd01/10458187/a75e90d90021/polymers-15-03333-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd01/10458187/643f95d775f6/polymers-15-03333-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd01/10458187/de5efb8eee49/polymers-15-03333-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd01/10458187/42fe40eaaf99/polymers-15-03333-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd01/10458187/24ca12d19d0f/polymers-15-03333-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd01/10458187/b0cf2e0c0fce/polymers-15-03333-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd01/10458187/43bef236ab04/polymers-15-03333-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd01/10458187/7470caffddf0/polymers-15-03333-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd01/10458187/218dc23dbbaa/polymers-15-03333-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd01/10458187/f8d4827a22a1/polymers-15-03333-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd01/10458187/c4bc97227027/polymers-15-03333-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd01/10458187/652172d44afc/polymers-15-03333-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd01/10458187/74263b122ebf/polymers-15-03333-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd01/10458187/d51f571d4afe/polymers-15-03333-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd01/10458187/a75e90d90021/polymers-15-03333-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd01/10458187/643f95d775f6/polymers-15-03333-g014.jpg

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