Lewis H, Straatsma B R, Foos R Y
Ophthalmology. 1986 Aug;93(8):1098-112. doi: 10.1016/s0161-6420(86)33615-7.
A clinicopathologic study of multiple extramacular drusen (MED) was performed on 784 eyes of 412 consecutive autopsies and on 100 eyes of 50 consecutive patients with MED. The clinical and histopathologic characteristics of MED and its correlation with reticular degeneration of the pigment epithelium (RDPE) and with macular degenerative abnormalities are presented. Multiple extramacular drusen was associated with macular degenerative abnormalities in 88% of autopsy cases, in contrast to 2% of cases in a control population without MED or RDPE. Multiple extramacular drusen and macular degenerative abnormalities are associated findings and apparently have similar pathogenetic mechanisms.
对412例连续尸检的784只眼以及50例连续患有多发性黄斑外玻璃膜疣（MED）患者的100只眼进行了多发性黄斑外玻璃膜疣的临床病理研究。阐述了MED的临床和组织病理学特征及其与色素上皮网状变性（RDPE）和黄斑变性异常的相关性。在88%的尸检病例中，多发性黄斑外玻璃膜疣与黄斑变性异常相关，相比之下，在没有MED或RDPE的对照人群中，这一比例为2%。多发性黄斑外玻璃膜疣和黄斑变性异常是相关发现，显然具有相似的发病机制。
