U.S. Department of Agriculture, Agricultural Research Service, Foreign Animal Disease Research Unit, Plum Island Animal Disease Center, Orient, NY 11957, USA.
U.S. Department of Agriculture, Agricultural Research Service, Foreign Animal Disease Research Unit, National Bio and Agro-Defense Facility, Unit Name, Manhattan, KS 66502, USA.
Viruses. 2023 Aug 11;15(8):1722. doi: 10.3390/v15081722.
African swine fever (ASF) is a lethal disease of domestic pigs that has been causing outbreaks for over a century in Africa ever since its first discovery in 1921. Since 1957, there have been sporadic outbreaks outside of Africa; however, no outbreak has been as devastating and as far-reaching as the current pandemic that originated from a 2007 outbreak in the Republic of Georgia. Derivatives with a high degree of similarity to the progenitor strain, ASFV-Georgia/2007, have been sequenced from various countries in Europe and Asia. However, the current strains circulating in Africa are largely unknown, and 24 different genotypes have been implicated in different outbreaks. In this study, ASF isolates were collected from samples from swine suspected of dying from ASF on farms in Ghana in early 2022. While previous studies determined that the circulating strains in Ghana were p72 Genotype I, we demonstrate here that the strains circulating in 2022 were derivatives of the p72 Genotype II pandemic strain. Therefore, this study demonstrates for the first time the emergence of Genotype II ASFV in Ghana.
非洲猪瘟（ASF）是一种致命的家猪疾病，自 1921 年首次发现以来，在非洲已经爆发了一个多世纪。自 1957 年以来，非洲以外地区也有零星爆发；然而，没有一次爆发像起源于 2007 年格鲁吉亚共和国的当前大流行那样具有破坏性和深远影响。与原毒株 ASFV-Georgia/2007 高度相似的衍生物已从欧洲和亚洲的不同国家进行了测序。然而，目前在非洲流行的毒株在很大程度上尚不清楚，并且 24 种不同的基因型与不同的爆发有关。在这项研究中，2022 年初在加纳农场疑似死于 ASF 的猪的样本中收集了 ASF 分离株。虽然之前的研究确定加纳流行的毒株是 p72 基因型 I，但我们在这里证明，2022 年流行的毒株是 p72 基因型 II 大流行毒株的衍生物。因此，本研究首次证明了基因型 II ASFV 在加纳的出现。
