情绪波动与颅内动脉瘤蛛网膜下腔出血有因果关系：一项孟德尔随机化研究。

Mood swings are causally associated with intracranial aneurysm subarachnoid hemorrhage: A Mendelian randomization study.

机构信息

Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Hunan International Scientific and Technological Cooperation Base of Brain Tumor Research, Xiangya Hospital, Central South University, Changsha, China.

出版信息

Brain Behav. 2023 Nov;13(11):e3233. doi: 10.1002/brb3.3233. Epub 2023 Aug 25.

DOI:10.1002/brb3.3233

PMID:37632147

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10636415/

Abstract

BACKGROUND

Mood swings have been observed in patients with intracranial aneurysm (IA), but it is still unknown whether mood swings can affect IA.

AIM

To explore the causal association between mood swings or experiencing mood swings and IA through a two-sample Mendelian randomization (MR) study.

METHODS

Summary-level statistics of mood swings, experiencing mood swings, IA, aneurysm-associated subarachnoid hemorrhage (aSAH), and non-ruptured IA (uIA) were collected from the genome-wide association study. Two-sample MR and various sensitivity analyses were employed to explore the causal association between mood swings or experiencing mood swings and IA, or aSAH, or uIA. The inverse-variance weighted method was used as the primary method.

RESULTS

Genetically determined mood swings (odds ratio [OR] = 5.23, 95% confidence interval (95%CI): 1.65-16.64, p = .005) and experiencing mood swings (OR = 2.50, 95%CI: 1.37-4.57, p = .003) were causally associated with an increased risk of IA. Mood swings (OR = 5.67, 95%CI: 1.40-23.04, p = .015) and experiencing mood swings were causally associated with the risk of aSAH (OR = 2.91, 95%CI: 1.47-5.75, p = .002). Neither mood swings (OR = 1.95, 95%CI: .31-12.29, p = .478) nor experiencing mood swings (OR = 1.20, 95%CI: .48-3.03, p = .693) were associated with uIA.

CONCLUSIONS

Mood swings and experiencing mood swings increased the risk of IA and aSAH incidence. These results suggest that alleviating mood swings may reduce IA rupture incidence and aSAH incidence.

摘要

背景

颅内动脉瘤（IA）患者会出现情绪波动，但目前尚不清楚情绪波动是否会影响 IA。

目的

通过两样本 Mendelian 随机化（MR）研究探讨情绪波动或经历情绪波动与 IA 之间的因果关系。

方法

从全基因组关联研究中收集了情绪波动、经历情绪波动、IA、动脉瘤相关性蛛网膜下腔出血（aSAH）和未破裂 IA（uIA）的汇总统计数据。采用两样本 MR 和各种敏感性分析来探讨情绪波动或经历情绪波动与 IA、aSAH 或 uIA 之间的因果关系。采用逆方差加权法作为主要方法。

结果

遗传决定的情绪波动（比值比 [OR] = 5.23，95%置信区间 [95%CI]：1.65-16.64，p =.005）和经历情绪波动（OR = 2.50，95%CI：1.37-4.57，p =.003）与 IA 风险增加有关。情绪波动（OR = 5.67，95%CI：1.40-23.04，p =.015）和经历情绪波动与 aSAH 风险有关（OR = 2.91，95%CI：1.47-5.75，p =.002）。情绪波动（OR = 1.95，95%CI：.31-12.29，p =.478）和经历情绪波动（OR = 1.20，95%CI：.48-3.03，p =.693）均与 uIA 无关。