Germani Marcelo, Almeida Claudia C M S, Munoz-Lora Victor R M, Rogério Victor, Moelhoff Nicholas, Freytag David L, Green Jeremy B, Alfertshofer Michael, Davidovic Kristina, Cotofana Sebastian
Private Office, Sao Paulo, Brazil.
Let's HOF Academy, Sao Paulo, Brazil.
J Cosmet Dermatol. 2023 Nov;22(11):2950-2956. doi: 10.1111/jocd.15970. Epub 2023 Aug 26.
A previous injection algorithm termed the "Toxin Lift" was recently introduced and described volume increases in the midface following neuromodulator treatments of the jawline. Increase in midfacial volume due to soft tissue repositioning could also affect the severity of infraorbital hollows.
The objective is therefore to evaluate whether the severity of infraorbital hollows can be improved by injecting neuromodulators in the supra-mandibular segment of the platysma.
A total of 35 volunteers (11 males/24 females) with a mean age of 39.8 (9.6) years and a mean BMI of 25.2 (5.2) kg/m were investigated. Bilateral infraorbital regions were evaluated via clinical assessment and semi-quantitative 3D imaging. The applied injection technique targeted the platysma via four injection points administering 5 I.U. per injection point resulting in a total of 20 I.U. per facial side.
Volume increase of the infraorbital region was 0.13 cc at 15 days (p = 0.001) and was 0.02 cc at 30 days (p = 0.452) whereas the skin displacement in cranial direction was 0.54 mm at 15 days (p < 0.001) and was 0.31 mm at 30 days (p < 0.001). Clinical evaluation revealed a highly statistically significant improvement of the tear trough, palpaebromalar groove, and of the lid-cheek junction when compared to baseline with all p < 0.001.
The results of this clinical prospective interventional analysis revealed that the "Toxin Lift" injection technique is capable to improve the clinical appearance of infraorbital hollows. The effects can be explained by the concepts of facial biomechanics.
最近引入了一种名为“毒素提升”的注射算法，该算法描述了在对下颌缘进行神经调节剂治疗后中面部的体积增加。由于软组织重新定位导致的中面部体积增加也可能影响眶下凹陷的严重程度。
因此，目的是评估通过在颈阔肌的下颌上节段注射神经调节剂是否可以改善眶下凹陷的严重程度。
共调查了35名志愿者（11名男性/24名女性），平均年龄39.8（9.6）岁，平均BMI为25.2（5.2）kg/m。通过临床评估和半定量3D成像对双侧眶下区域进行评估。应用的注射技术通过四个注射点靶向颈阔肌，每个注射点注射5国际单位，每侧面部总共注射20国际单位。
眶下区域的体积在15天时增加了0.13立方厘米（p = 0.001），在30天时增加了0.02立方厘米（p = 0.452），而在头侧方向的皮肤位移在15天时为0.54毫米（p < 0.001），在30天时为0.31毫米（p < 0.001）。临床评估显示，与基线相比，泪沟、睑颧沟和睑颊交界处有高度统计学意义的改善，所有p < 0.001。
这项临床前瞻性干预分析的结果表明，“毒素提升”注射技术能够改善眶下凹陷的临床表现。这些效果可以用面部生物力学的概念来解释。
