Department of Biotechnology, Faculty of Science and Humanities, SRM Institute of Science and Technology, Kattankulathur - 603 203, Chengalpattu District, Tamil Nadu, India.
Department of Biotechnology, Faculty of Science and Humanities, SRM Institute of Science and Technology, Kattankulathur - 603 203, Chengalpattu District, Tamil Nadu, India.
Microb Pathog. 2023 Oct;183:106324. doi: 10.1016/j.micpath.2023.106324. Epub 2023 Aug 24.
Actinobacteria are gram-positive bacteria with high G:C ratio in their genetic makeup. They have been noted and studied for their capacity to produce bioactive substances with a range of uses in human health, and they also exhibit a unique property of adapting to extreme environments quite well. Actinobacteria may play an essential role in cancer prevention and treatment due to their synthesis of anticancer compounds, as indicated by recent studies. The aim of this review is to give a summary of what is currently known about the connection between actinobacteria and different types of cancer. This paper delineates the diverse array of actinobacterial bioactive compounds possessing anticancer properties, elucidates their mechanisms of action and explores potential applications in cancer treatment. Furthermore, this review highlights how the microbiome influences the onset and progression of cancer, as well as the discussing the potential benefits that actinobacteria may bring in terms of controlling the microbiome and contributing to the regulation of the tumour microenvironment to cure or prevent cancer.
放线菌是革兰氏阳性菌，其遗传物质中的 G+C 比例很高。它们因其能够产生具有广泛用途的生物活性物质而被注意和研究，并且它们还表现出适应极端环境的独特能力。最近的研究表明，放线菌可能在癌症的预防和治疗中发挥重要作用，因为它们能够合成抗癌化合物。本综述的目的是总结目前已知的放线菌与不同类型癌症之间的联系。本文概述了具有抗癌特性的多种放线菌生物活性化合物，阐明了它们的作用机制，并探讨了它们在癌症治疗中的潜在应用。此外，本综述还强调了微生物组如何影响癌症的发生和发展，以及讨论了放线菌在控制微生物组和有助于调节肿瘤微环境以治疗或预防癌症方面可能带来的潜在益处。
