Classification of cancer cells and gene selection based on microarray data using MOPSO algorithm.

PURPOSE

Microarray information is crucial for the identification and categorisation of malignant tissues. The very limited sample size in the microarray has always been a challenge for classification design in cancer research. As a result, by pre-processing gene selection approaches and genes lacking their information, the microarray data are deleted prior to categorisation. In essence, an appropriate gene selection technique can significantly increase the accuracy of illness (cancer) classification.

METHODS

For the classification of high-dimensional microarray data, a novel approach based on the hybrid model of multi-objective particle swarm optimisation (MOPSO) is proposed in this research. First, a binary vector representing each particle's position is presented at random. A gene is represented by each bit. Bit 0 denotes the absence of selection of the characteristic (gene) corresponding to it, while bit 1 denotes the selection of the gene. Therefore, the position of each particle represents a set of genes, and the linear Bayesian discriminant analysis classification algorithm calculates each particle's degree of fitness to assess the quality of the gene set that particle has chosen. The suggested methodology is applied to four different cancer database sets, and the results are contrasted with those of other approaches currently in use.

RESULTS

The proposed algorithm has been applied on four sets of cancer database and its results have been compared with other existing methods. The results of the implementation show that the improvement of classification accuracy in the proposed algorithm compared to other methods for four sets of databases is 25.84% on average. So that it has improved by 18.63% in the blood cancer database, 24.25% in the lung cancer database, 27.73% in the breast cancer database, and 32.80% in the prostate cancer database. Therefore, the proposed algorithm is able to identify a small set of genes containing information in a way choose to increase the classification accuracy.

CONCLUSION

Our proposed solution is used for data classification, which also improves classification accuracy. This is possible because the MOPSO model removes redundancy and reduces the number of redundant and redundant genes by considering how genes are correlated with each other.