Kobylyansky A G, Nagornaya L V, Yarygin K N, Titov M I
Peptides. 1986 Jul-Aug;7(4):551-6. doi: 10.1016/0196-9781(86)90025-2.
Met- and Leu-enkephalin applied subarachnoidally into the rostral portion of a transected spinal cord (at the T6-T7 level) induce postural asymmetry of the hind limbs in rats, Met-enkephalin being predominantly responsible for the flexion of the right, and Leu-enkephalin of the left, hind leg. The blood serum of rats injected with Met-enkephalin contains a factor which, when administered subarachnoidally into the caudal portion of the transected spinal cord, is capable of inducing the hind limb postural asymmetry--predominantly, with the right leg flexion. This factor is inactivated by papain and differs from Met- and Leu-enkephalin in chromatographic properties. Apparently, Met-enkephalin induces the release of a peptide factor into the blood, from the brain or organs innervated by the neurons lying above the cut. It is then carried with the blood to the hind limbs and effects the hind limb postural asymmetry.
将甲硫氨酸脑啡肽和亮氨酸脑啡肽蛛网膜下注射到横断脊髓（T6 - T7水平）的头端部分，可诱发大鼠后肢姿势不对称，甲硫氨酸脑啡肽主要导致右后肢屈曲，亮氨酸脑啡肽主要导致左后肢屈曲。注射甲硫氨酸脑啡肽的大鼠血清中含有一种因子，将其蛛网膜下注射到横断脊髓的尾端部分时，能够诱发后肢姿势不对称——主要是右腿屈曲。该因子可被木瓜蛋白酶灭活，在色谱特性上与甲硫氨酸脑啡肽和亮氨酸脑啡肽不同。显然，甲硫氨酸脑啡肽促使一种肽因子从脑或由切断上方神经元支配的器官释放到血液中。然后，它随血液到达后肢并影响后肢姿势不对称。
