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The emerging fentanyl-xylazine syndemic in the USA: challenges and future directions.

作者信息

Zhu David T, Friedman Joseph, Bourgois Philippe, Montero Fernando, Tamang Suzanne

机构信息

Medical Scientist Training Program, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.

Medical Scientist Training Program, University of California Los Angeles, Los Angeles, CA, USA.

出版信息

Lancet. 2023 Nov 25;402(10416):1949-1952. doi: 10.1016/S0140-6736(23)01686-0. Epub 2023 Aug 24.

DOI:10.1016/S0140-6736(23)01686-0
PMID:37634523
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10842070/
Abstract
摘要

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2
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Integrating public health and translational basic science to address challenges of xylazine adulteration of fentanyl.整合公共卫生与转化基础科学以应对芬太尼中掺入赛拉嗪的挑战。
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本文引用的文献

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The first drug-related death associated with xylazine use in the UK and Europe.在英国和欧洲，首例与使用苯环己哌啶相关的药物致死案例。
J Forensic Leg Med. 2023 Jul;97:102542. doi: 10.1016/j.jflm.2023.102542. Epub 2023 May 22.
2
Here's What to Know About Xylazine, aka Tranq, the Animal Tranquilizer Increasingly Found in Illicit Fentanyl Samples.以下是关于赛拉嗪（又名Tranq）的相关信息，这种动物用镇静剂越来越多地出现在非法芬太尼样本中。
JAMA. 2023 Jun 13;329(22):1904-1906. doi: 10.1001/jama.2023.8625.
3
Xylazine - Medical and Public Health Imperatives.赛拉嗪——医学与公共卫生的当务之急。
N Engl J Med. 2023 Jun 15;388(24):2209-2212. doi: 10.1056/NEJMp2303120. Epub 2023 Apr 26.
4
Potency-Enhancing Synthetics in the Drug Overdose Epidemic: Xylazine ("Tranq"), Fentanyl, Methamphetamine, and the Displacement of Heroin in Philadelphia and Tijuana.药物过量流行中的效力增强合成药物：赛拉嗪（“tranq”）、芬太尼、甲基苯丙胺以及费城和蒂华纳海洛因的替代情况
J Illicit Econ Dev. 2022;4(2):204-222. doi: 10.31389/jied.122. Epub 2022 Dec 2.
5
Xylazine in the Opioid Epidemic: A Systematic Review of Case Reports and Clinical Implications.阿片类药物流行中的赛拉嗪：病例报告及临床意义的系统评价
Cureus. 2023 Mar 29;15(3):e36864. doi: 10.7759/cureus.36864. eCollection 2023 Mar.
6
Perspectives of people in Philadelphia who use fentanyl/heroin adulterated with the animal tranquilizer xylazine; Making a case for xylazine test strips.费城使用掺有动物镇静剂赛拉嗪的芬太尼/海洛因者的观点；支持赛拉嗪检测试纸的理由。
Drug Alcohol Depend Rep. 2022 Jun 30;4:100074. doi: 10.1016/j.dadr.2022.100074. eCollection 2022 Sep.
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Xylazine spreads across the US: A growing component of the increasingly synthetic and polysubstance overdose crisis.赛拉嗪在美国蔓延：日益合成化和多物质过量危机中不断增加的一个因素。
Drug Alcohol Depend. 2022 Apr 1;233:109380. doi: 10.1016/j.drugalcdep.2022.109380. Epub 2022 Feb 26.
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Effectiveness of Policies for Addressing the US Opioid Epidemic: A Model-Based Analysis from the Stanford-Lancet Commission on the North American Opioid Crisis.应对美国阿片类药物流行政策的有效性：来自斯坦福-柳叶刀北美阿片类药物危机委员会的基于模型的分析
Lancet Reg Health Am. 2021 Nov;3. doi: 10.1016/j.lana.2021.100031. Epub 2021 Jul 31.
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Implementing harm reduction in non-urban communities affected by opioids and polysubstance use: A qualitative study exploring challenges and mitigating strategies.在受阿片类药物和多药物使用影响的非城市社区实施减少伤害：一项探索挑战和缓解策略的定性研究。
Int J Drug Policy. 2021 Apr;90:103080. doi: 10.1016/j.drugpo.2020.103080. Epub 2020 Dec 16.
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Use of rapid fentanyl test strips among young adults who use drugs.快速芬太尼检测条在药物使用的青年中的使用情况。
Int J Drug Policy. 2018 Nov;61:52-58. doi: 10.1016/j.drugpo.2018.09.009. Epub 2018 Oct 18.