Department of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
J Clin Exp Hematop. 2023 Sep 28;63(3):143-151. doi: 10.3960/jslrt.23012. Epub 2023 Aug 28.
Follicular lymphoma (FL) is the most frequent indolent lymphoma and is characterized by the abundant infiltration of tumor microenvironment (TME) cells. The activity of TME cells reportedly plays an important role in the biology of FL. TME cells that reside within neoplastic follicles, such as T-follicular helper cells and follicular dendritic cells, have been shown to aid in FL development and progression through interactions with malignant B cells, whereas regulatory T cells have unexpectedly shown an apparently favorable prognostic impact in FL. Unfortunately, the understanding of the FL TME, particularly regarding minor cell subsets, has been hampered by unknown cell heterogeneity. As with other solid and hematologic cancers, novel single-cell analysis technologies have recently been applied to FL research and have uncovered previously unrecognized heterogeneities, not only in malignant B cells but also in TME cells. These reports have greatly increased the resolution of our understanding of the FL TME and, at the same time, raised questions about newly identified TME cells. This review provides an overview of the unique aspects of FL TME cells with a clinical viewpoint and highlights recent discoveries from single-cell analysis, while also suggesting potential future directions.
滤泡性淋巴瘤（FL）是最常见的惰性淋巴瘤，其特征是大量肿瘤微环境（TME）细胞浸润。据报道，TME 细胞的活性在 FL 的生物学中起着重要作用。存在于肿瘤滤泡内的 TME 细胞，如 T 滤泡辅助细胞和滤泡树突状细胞，已被证明通过与恶性 B 细胞相互作用有助于 FL 的发展和进展，而调节性 T 细胞在 FL 中出人意料地表现出明显有利的预后影响。不幸的是，对 FL TME 的理解，特别是对小细胞亚群的理解，一直受到未知细胞异质性的阻碍。与其他实体瘤和血液系统恶性肿瘤一样，新型单细胞分析技术最近已应用于 FL 研究，并揭示了以前未被识别的异质性，不仅在恶性 B 细胞中，而且在 TME 细胞中也是如此。这些报告极大地提高了我们对 FL TME 的理解分辨率，同时也对新发现的 TME 细胞提出了疑问。本综述从临床角度概述了 FL TME 细胞的独特方面，并强调了单细胞分析的最新发现，同时还提出了潜在的未来方向。
