Barr G D, Shale D J, Jewell D P
Postgrad Med J. 1986 May;62(727):341-5. doi: 10.1136/pgmj.62.727.341.
Ulcerative colitis is not commonly associated with recognizable pulmonary disease and only four sporadic cases of sarcoidosis in association with ulcerative colitis have been previously reported. However, in a series of 680 patients with ulcerative colitis, pulmonary or extra-pulmonary sarcoidosis has at some stage been present in eight. These cases are reported in detail. The onset of either condition bore no relationship to the activity or the presence of recognized peripheral manifestations of the other, suggesting that the two diseases were independent. However, three of the patients had the HLA B8 DR3 phenotype which is a higher prevalence than seen in previous studies of either disease alone. Patients with ulcerative colitis who possess this HLA phenotype may possibly be more susceptible to developing sarcoidosis.
溃疡性结肠炎通常与可识别的肺部疾病无关，此前仅报告过4例与溃疡性结肠炎相关的结节病散发病例。然而，在一组680例溃疡性结肠炎患者中，有8例在某个阶段出现了肺部或肺外结节病。现将这些病例详细报告如下。两种疾病的发病均与另一种疾病的活动或已确认的外周表现无关，这表明这两种疾病是独立的。然而，其中3例患者具有HLA B8 DR3表型，其患病率高于以往单独对这两种疾病的研究。具有这种HLA表型的溃疡性结肠炎患者可能更容易患结节病。
