结节病中的HLA关联：两个种族群体的研究
HLA associations in sarcoidosis: a study of two ethnic groups.
作者信息
Gardner J, Kennedy H G, Hamblin A, Jones E
出版信息
Thorax. 1984 Jan;39(1):19-22. doi: 10.1136/thx.39.1.19.
Abstract
We report results of HLA-A, B, C, and DR typing in groups of white Caucasians of English descent and black West Indians of African descent with sarcoidosis. In the English patients we found a significantly increased frequency of Cw7, which was not found in the West Indian patients. Our results also suggest that DR3 and, in particular, inheritance of the B8/Cw7/DR3 haplotype is associated with good prognosis in English patients with sarcoidosis. There was no association between any HLA antigen and prognosis in the West Indian patients in this study.
摘要
我们报告了对患有结节病的英格兰裔白种人和非洲裔西印度黑人进行HLA - A、B、C和DR分型的结果。在英格兰患者中，我们发现Cw7的频率显著增加，而在西印度患者中未发现。我们的结果还表明，DR3，尤其是B8/Cw7/DR3单倍型的遗传与英格兰结节病患者的良好预后相关。在本研究中，西印度患者的任何HLA抗原与预后之间均无关联。
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