van Dijk J G, Frŏlich M, Brand E C, van Hall E V
Fertil Steril. 1979 May;31(5):481-5. doi: 10.1016/s0015-0282(16)43989-0.
In order to investigate the possible stimulating effect of danazol on fertility, a randomized clinical trial was performed on 40 women with unexplained infertility. Of these 40 women, 21 received 200 mg of danazol daily for 100 days and 19 received a placebo treatment during the same period. Serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin, estrone, estradiol, progesterone, and testosterone were followed before, during, and after treatment. Danazol administration induced anovulation in all women, with prompt resumption of normal ovulatory function after discontinuation of the drug. No influence was seen on serum LH, FSH, and testosterone levels, but serum estrone, estradiol, and progesterone levels decreased significantly during treatment. Serum prolactin levels also decreased, but not significantly. No pregnancies occurred in the placebo group during a 6-month follow-up period. In the danazol group, five pregnancies occurred, of which two were ectopic and three went to term. The difference in pregnancy rate between both groups was statistically significant (P less than 0.05).
为了研究达那唑对生育能力可能的刺激作用，对40例不明原因不孕症女性进行了一项随机临床试验。在这40名女性中，21名每天接受200毫克达那唑治疗，持续100天，19名在同一时期接受安慰剂治疗。在治疗前、治疗期间和治疗后跟踪监测血清促黄体生成素（LH）、促卵泡生成素（FSH）、催乳素、雌酮、雌二醇、孕酮和睾酮的水平。服用达那唑导致所有女性无排卵，停药后排卵功能迅速恢复正常。未观察到达那唑对血清LH、FSH和睾酮水平有影响，但治疗期间血清雌酮、雌二醇和孕酮水平显著下降。血清催乳素水平也有所下降，但不显著。在6个月的随访期内，安慰剂组未发生妊娠。在达那唑组，有5例妊娠，其中2例为异位妊娠，3例足月分娩。两组妊娠率的差异具有统计学意义（P小于0.05）。
