Tamaya T, Murakami T, Yamada T, Wada K, Fujimoto J, Okada H
Fertil Steril. 1983 Nov;40(5):585-9. doi: 10.1016/s0015-0282(16)47413-3.
This study was designed to clarify the effects of danazol on levels of serum luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin, progesterone (P), and 17 beta-estradiol and endometrial steroid receptors (for estrogen [ER], progestin [PR], and androgen [AR] ) during luteal-phase and long-term treatment. These levels were compared with midluteal-phase levels for a histologically in-phase endometrium. Danazol given during the luteal phase to patients with in-phase endometrium decreased endometrial steroid receptor levels (total ER and total PR), and decreased serum P, LH, and FSH levels. Ten of the 17 patients treated (59%) still had in-phase endometrium. Danazol (400 mg/day) given for 1 month or more to patients with pelvic endometriosis increased serum LH and FSH levels within the normal range and endometrial total ER and PR levels. It appears that the effects of short-term and long-term treatment with danazol on serum hormone and endometrial steroid receptor levels differ.
本研究旨在阐明达那唑在黄体期及长期治疗期间对血清促黄体生成素（LH）、促卵泡生成素（FSH）、催乳素、孕酮（P）和17β-雌二醇水平以及子宫内膜甾体激素受体（雌激素受体[ER]、孕激素受体[PR]和雄激素受体[AR]）的影响。将这些水平与组织学上同期子宫内膜的黄体中期水平进行比较。给同期子宫内膜患者在黄体期给予达那唑可降低子宫内膜甾体激素受体水平（总ER和总PR），并降低血清P、LH和FSH水平。17例接受治疗的患者中有10例（59%）仍有同期子宫内膜。给盆腔子宫内膜异位症患者给予达那唑（400mg/天）1个月或更长时间可使血清LH和FSH水平升高至正常范围，并使子宫内膜总ER和PR水平升高。看来达那唑短期和长期治疗对血清激素和子宫内膜甾体激素受体水平的影响有所不同。
