Molecular Physiology, Institute of Cardiovascular Physiology, University Medical Center, Georg-August-University, Göttingen, Germany.
EMBO J. 2023 Oct 4;42(19):e114986. doi: 10.15252/embj.2023114986. Epub 2023 Aug 28.
Although ion transporters and channels have been extensively studied over the last couple of decades, there are still unresolved aspects with regards to their contribution to cancer cell biology. Recent work by Folcher et al (2023) reports a critical role for Na leak channel NALCN in metastatic prostate cancer. The study demonstrates that NALCN promotes metastatic spread to distant organs by controlling Ca signaling.
尽管离子转运体和通道在过去几十年中得到了广泛研究，但它们对癌细胞生物学的贡献仍有一些未解之谜。Folcher 等人（2023 年）的最新研究报告了 Na 渗漏通道 NALCN 在转移性前列腺癌中的关键作用。该研究表明，NALCN 通过控制 Ca 信号来促进转移性肿瘤向远处器官的扩散。
