聚焦癌症代谢中的GOT2。
Spotlight on GOT2 in Cancer Metabolism.
作者信息
Kerk Samuel A, Garcia-Bermudez Javier, Birsoy Kivanc, Sherman Mara H, Shah Yatrik M, Lyssiotis Costas A
机构信息
Doctoral Program in Cancer Biology, University of Michigan, Ann Arbor, MI, USA.
Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
出版信息
Onco Targets Ther. 2023 Aug 22;16:695-702. doi: 10.2147/OTT.S382161. eCollection 2023.
GOT2 is at the nexus of several critical metabolic pathways in homeostatic cellular and dysregulated cancer metabolism. Despite this, recent work has emphasized the remarkable plasticity of cancer cells to employ compensatory pathways when GOT2 is inhibited. Here, we review the metabolic roles of GOT2, highlighting findings in both normal and cancer cells. We emphasize how cancer cells repurpose cell intrinsic metabolism and their flexibility when GOT2 is inhibited. We close by using this framework to discuss key considerations for future investigations into cancer metabolism.
谷草转氨酶2（GOT2）处于细胞内稳态和失调的癌症代谢中多个关键代谢途径的交汇处。尽管如此，最近的研究强调了癌细胞在GOT2受到抑制时利用补偿途径的显著可塑性。在这里，我们回顾了GOT2的代谢作用，突出了在正常细胞和癌细胞中的研究发现。我们强调了癌细胞在GOT2受到抑制时如何重新利用细胞内固有的代谢及其灵活性。最后，我们利用这个框架来讨论未来癌症代谢研究的关键考虑因素。
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