迈向使用布里渊成像光谱法进行周围神经力学特性分析
Toward peripheral nerve mechanical characterization using Brillouin imaging spectroscopy.
作者信息
Cheburkanov Vsevolod, Du Junwei, Brogan David M, Berezin Mikhail Y, Yakovlev Vladislav V
机构信息
Texas A&M University, Department of Biomedical Engineering, College Station, Texas, United States.
Washington University School of Medicine, Department of Radiology, St. Louis, Missouri, United States.
出版信息
Neurophotonics. 2023 Jul;10(3):035007. doi: 10.1117/1.NPh.10.3.035007. Epub 2023 Aug 26.
SIGNIFICANCE
Peripheral nerves are viscoelastic tissues with unique elastic characteristics. Imaging of peripheral nerve elasticity is important in medicine, particularly in the context of nerve injury and repair. Elasticity imaging techniques provide information about the mechanical properties of peripheral nerves, which can be useful in identifying areas of nerve damage or compression, as well as assessing the success of nerve repair procedures.
AIM
We aim to assess the feasibility of Brillouin microspectroscopy for peripheral nerve imaging of elasticity, with the ultimate goal of developing a new diagnostic tool for peripheral nerve injury .
APPROACH
Viscoelastic properties of the peripheral nerve were evaluated with Brillouin imaging spectroscopy.
RESULTS
An external stress exerted on the fixed nerve resulted in a Brillouin shift. Quantification of the shift enabled correlation of the Brillouin parameters with nerve elastic properties.
CONCLUSIONS
Brillouin microscopy provides sufficient sensitivity to assess viscoelastic properties of peripheral nerves.
意义
周围神经是具有独特弹性特征的粘弹性组织。周围神经弹性成像在医学中很重要，特别是在神经损伤和修复的背景下。弹性成像技术提供有关周围神经力学特性的信息，这对于识别神经损伤或受压区域以及评估神经修复程序的成功与否可能是有用的。
目的
我们旨在评估布里渊显微光谱法用于周围神经弹性成像的可行性，最终目标是开发一种用于周围神经损伤的新型诊断工具。
方法
用布里渊成像光谱法评估周围神经的粘弹性特性。
结果
施加在固定神经上的外部应力导致布里渊频移。对该频移进行量化可使布里渊参数与神经弹性特性相关联。
结论
布里渊显微镜提供了足够的灵敏度来评估周围神经的粘弹性特性。
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