Di Lernia Vito, Peccerillo Francesca, Ficarelli Elena
Dermatology Unit, Azienda Unità Sanitaria Locale- IRCCS di Reggio Emilia, Reggio Emilia, Italy.
Psoriasis (Auckl). 2023 Aug 22;13:27-31. doi: 10.2147/PTT.S417427. eCollection 2023.
A standardised therapeutic approach to coexistent psoriasis and bullous pemphigoid is lacking, although psoriasis is associated with an increased risk of developing bullous pemphigoid. Here, we report an elderly psoriatic patient who developed a refractory bullous pemphigoid and experienced clearance of both diseases following treatment with dymethylfumarate. Due to lymphopenia, this treatment was stopped and the patient was administered risankizumab without relapses. Dymethylfumarate may be able to inhibit the recruitment of neutrophils and monocytes into the skin. Therefore, thanks to pleiotropic effects, dymethylfumarate could be an effective treatment in psoriatic patients who develop bullous pemphigoid.
虽然银屑病与发生大疱性类天疱疮的风险增加有关，但目前缺乏针对银屑病和大疱性类天疱疮共存的标准化治疗方法。在此，我们报告一名老年银屑病患者，其发生了难治性大疱性类天疱疮，在接受富马酸二甲酯治疗后两种疾病均得到缓解。由于淋巴细胞减少，该治疗被停止，患者改用司库奇尤单抗治疗且未复发。富马酸二甲酯可能能够抑制中性粒细胞和单核细胞向皮肤的募集。因此，由于其多效性作用，富马酸二甲酯可能是治疗发生大疱性类天疱疮的银屑病患者的一种有效疗法。
