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外阴硬化性苔藓及萎缩性苔藓：对标准治疗无效。

Vulvar Lichen Sclerosus Et Atrophicus: Refractory to Standard Therapy.

作者信息

Luqman Thasneem S, Kalavant Akshay, Sunil Kumar K S, Swathy A R

机构信息

Department of Emergency Medicine, Trivandrum Medical College, Thiruvananthapuram, Kerala, India.

Department of Pediatric Surgery, Shri Dharmasthala Manjunatheshwara University, Karnataka, India.

出版信息

J Indian Assoc Pediatr Surg. 2023 Jul-Aug;28(4):345-347. doi: 10.4103/jiaps.jiaps_188_21. Epub 2023 Jul 11.

DOI:10.4103/jiaps.jiaps_188_21
PMID:37635892
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10455703/
Abstract

Vulvar lichen sclerosus et atrophicus is an inflammatory disease which can affect the pediatric age group, although rarely. Its prevalence is underestimated. It may have genital or extragenital manifestations. If left untreated, it may progress to complications which hamper the quality of life. The treatment of choice is topical clobetasol propionate. Here, we present a case of prepubertal vulvar LS, which was refractory to topical clobetasol but responded to topical tacrolimus application.

摘要

外阴硬化性苔藓是一种炎症性疾病，虽很少见，但可累及儿童年龄组。其患病率被低估。它可能有生殖器或生殖器外表现。如果不治疗，可能会进展为影响生活质量的并发症。首选治疗方法是外用丙酸氯倍他索。在此，我们报告一例青春期前外阴硬化性苔藓病例，该病例对外用丙酸氯倍他索治疗无效，但外用他克莫司有效。

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本文引用的文献

1
Evidence-based (S3) Guideline on (anogenital) Lichen sclerosus.基于循证医学的（肛门生殖器）硬化性苔藓（S3）指南。
J Eur Acad Dermatol Venereol. 2015 Oct;29(10):e1-43. doi: 10.1111/jdv.13136. Epub 2015 Jul 22.
2
The surgical management of complications of vulval lichen sclerosus.外阴硬化性苔藓并发症的手术治疗。
Eur J Obstet Gynecol Reprod Biol. 2012 May;162(1):79-82. doi: 10.1016/j.ejogrb.2012.01.016. Epub 2012 Mar 6.
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A double-blind, randomized controlled trial of clobetasol versus pimecrolimus in patients with vulvar lichen sclerosus.
一项比较卤米松与吡美莫司治疗外阴硬化性苔藓的双盲、随机对照临床试验。
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New surgical approach to lichen sclerosus of the vulva: the role of adipose-derived mesenchymal cells and platelet-rich plasma in tissue regeneration.外阴硬化性苔藓的新手术方法：脂肪来源间充质细胞和富血小板血浆在组织再生中的作用
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Infantile perineal protrusion.婴儿会阴突出。
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Childhood vulvar lichen sclerosus: an increasingly common problem.儿童外阴硬化性苔藓：一个日益常见的问题。
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Lichen sclerosus.硬化性苔藓
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