Laboratory of Pharmaceutical Analysis, School of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, GR-54124, Greece.
Laboratory of Analytical Chemistry, School of Chemistry, Faculty of Sciences, Aristotle University of Thessaloniki, GR-54124, Greece.
Bioanalysis. 2023 Aug;15(15):937-954. doi: 10.4155/bio-2023-0121. Epub 2023 Aug 28.
Microextraction techniques have attracted the attention of many researchers working in the field of bioanalysis due to their unique advantages, mainly in downsizing the scale of sample preparation steps. In parallel, analytical derivatization offers a powerful combination in terms of additional sensitivity, selectivity and compatibility with modern separation techniques. The aim of this review is to discuss the most recent advances in bioanalytical sample preparation based on the combination of microextraction and analytical derivatization. Both innovative fundamental reports and analyte-targeted applications are included and discussed. Dispersive liquid-liquid extraction and solid-phase microextraction are the most common techniques that typically combined with derivatization, while the development of novel and greener protocols is receiving substantial consideration in the field of analytical chemistry.
微萃取技术因其独特的优势，主要是在缩小样品制备步骤的规模方面，引起了许多从事生物分析领域的研究人员的关注。与此同时，分析衍生化在提高灵敏度、选择性和与现代分离技术的兼容性方面提供了强大的组合。本综述的目的是讨论基于微萃取和分析衍生化结合的生物分析样品制备的最新进展。包括和讨论了创新性的基础报告和针对分析物的应用。分散液相-液相萃取和固相微萃取是最常见的与衍生化相结合的技术，而在分析化学领域，新型和更环保的方案的发展受到了极大的关注。
