Lindman Jens, Yadav Anubha, Gising Johan, Larhed Mats
Department of Medicinal Chemistry, Uppsala University, Husargatan 3, SE-751 23 Uppsala, Sweden.
J Org Chem. 2023 Sep 15;88(18):12978-12985. doi: 10.1021/acs.joc.3c00972. Epub 2023 Aug 28.
A palladium(0)-catalyzed aminocarbonylation reaction employing molybdenum hexacarbonyl as a carbon monoxide precursor for the production of N-capped amino acids using aryl and heteroaryl bromides and triflates is reported. The carbon monoxide is formed through the use of a two-chamber system, where carbon monoxide generated in one chamber is free to diffuse over and be consumed in the other palladium-catalyzed reaction chamber. Using this method, two series of aryl bromides and aryl triflates were utilized to synthesize 21 N-capped amino acids in isolated yields between 40 and 91%.
报道了一种钯(0)催化的氨羰基化反应，该反应使用六羰基钼作为一氧化碳前体，以芳基和杂芳基溴化物及三氟甲磺酸酯为原料制备N-封端氨基酸。一氧化碳通过双室系统生成，在一个室中生成的一氧化碳可自由扩散并在另一个钯催化反应室中被消耗。利用该方法，使用了两个系列的芳基溴化物和芳基三氟甲磺酸酯来合成21种N-封端氨基酸，分离产率在40%至91%之间。
