Li Kailang, Xia Yongming, He Jian, Wang Jie, Li Jingyun, Ye Meng, Jin Xiaofeng
Department of Oncology, The First Hospital of Ningbo University, Ningbo, 315020, China.
Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Health Science Center, Ningbo University, Ningbo, 315211, China.
J Cancer Res Clin Oncol. 2023 Nov;149(17):16123-16146. doi: 10.1007/s00432-023-05310-z. Epub 2023 Aug 28.
The cancer occurrence and progression are largely affected by the post-translational modifications (PTMs) of proteins. Currently, it has been shown that the relationship between ubiquitination and SUMOylation is highly complex and interactive. SUMOylation affects the process of ubiquitination and degradation of substrates. Contrarily, SUMOylation-related proteins are also regulated by the ubiquitination process thus altering their protein levels or activity. Emerging evidence suggests that the abnormal regulation between this crosstalk may lead to tumorigenesis.
In this review, we have discussed the study of the relationship between ubiquitination and SUMOylation, as well as the possibility of a corresponding application in tumor therapy.
The relevant literatures from PubMed have been reviewed for this article.
The interaction between ubiquitination and SUMOylation is crucial for the occurrence and development of cancer. A greater understanding of the crosstalk of SUMOylation and ubiquitination may be more conducive to the development of more selective and effective SUMOylation inhibitors, as well as a promotion of synergy with other tumor treatment strategies.
蛋白质的翻译后修饰（PTM）在很大程度上影响癌症的发生和发展。目前，已有研究表明泛素化与类泛素化修饰（SUMOylation）之间的关系高度复杂且相互作用。SUMOylation影响底物的泛素化和降解过程。相反，SUMOylation相关蛋白也受泛素化过程的调控，从而改变其蛋白水平或活性。新出现的证据表明，这种相互作用之间的异常调节可能导致肿瘤发生。
在本综述中，我们讨论了泛素化与SUMOylation之间关系的研究，以及其在肿瘤治疗中相应应用的可能性。
本文回顾了来自PubMed的相关文献。
泛素化与SUMOylation之间的相互作用对癌症的发生和发展至关重要。更深入地了解SUMOylation和泛素化的相互作用可能更有利于开发更具选择性和有效性的SUMOylation抑制剂，并促进与其他肿瘤治疗策略的协同作用。
