佛波酯（12-0-十四酰佛波醇-13-乙酸酯）应用于无毛小鼠皮肤时的致癌作用。
The carcinogenic effect of TPA (12-0-tetradecanoylphorbol-13-acetate) when applied to the skin of hairless mice.
作者信息
Iversen U M, Iversen O H
出版信息
Virchows Arch B Cell Pathol Incl Mol Pathol. 1979 May 4;30(1):33-42. doi: 10.1007/BF02889088.
Groups of hairless mice received one, two, five and fifty applications of 20 nmoles TPA (12-0-tetradecanoylphorbol-13-acetate) on the skin of the back, and were observed for 20 months. The animals developed some papillomas, some squamous cell carcinomas, some fibrosarcomas of the dermis, and some malignant and benign tumours in internal organs. There was a small, not significantly different, incidence of benign and malignant tumours after 1, 2 and 5 paintings, and a significantly higher tumour incidence after 50 applications. Apart from reticuloses, which are commonly seen in these animals, the occurrence of other tumours is believed to be related to the TPA treatment. The results are interpreted as showing that TPA, like croton oil, should be regarded as a complete carcinogen.
将无毛小鼠分组，在其背部皮肤分别涂抹1次、2次、5次和50次20纳摩尔的佛波酯（12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯），并观察20个月。这些动物长出了一些乳头状瘤、一些鳞状细胞癌、一些真皮纤维肉瘤以及一些内脏的恶性和良性肿瘤。涂抹1次、2次和5次后，良性和恶性肿瘤的发生率较低，且无显著差异；涂抹50次后，肿瘤发生率显著升高。除了这些动物中常见的网状细胞增生症外，其他肿瘤的发生被认为与佛波酯治疗有关。结果表明，佛波酯与巴豆油一样，应被视为一种完全致癌物。
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