皮肤致癌性四氮唑试验中的剂量反应。
Dose response in the tetrazolium test for skin carcinogenicity.
作者信息
Iversen O H
出版信息
Br J Cancer. 1980 Mar;41(3):469-73. doi: 10.1038/bjc.1980.71.
The tetrazolium test for skin carcinogenicity was performed with different doses of (i) a strong, complete carcinogen with moderate cytotoxicity, 20-methylcholanthrene; (ii) a weak carcinogen with strong cytotoxicity, the promoter 12-O-tetradecanoylphorbol-13-acetate; (iii) a strong toxic substance with very weak carcinogenicity for the skin, cantharidin; and (iv) X-rays. The dose-response relationship was determined, and the validity of the tetrazolium test was confirmed. However, substances strongly cytotoxic must be tested in small doses to avoid necrosis. The tetrazolium test should not be used on the skin to test substances carcinogenic for organs other than skin.
采用不同剂量的以下物质进行皮肤致癌性的四氮唑试验
(i) 一种具有中等细胞毒性的强完全致癌物，20-甲基胆蒽；(ii) 一种具有强细胞毒性的弱致癌物，促癌剂12-O-十四酰佛波醇-13-乙酸酯；(iii) 一种对皮肤致癌性非常弱的强毒性物质，斑蝥素；以及(iv) X射线。确定了剂量反应关系，并证实了四氮唑试验的有效性。然而，必须以小剂量测试具有强细胞毒性的物质，以避免坏死。四氮唑试验不应在皮肤上用于测试对皮肤以外器官具有致癌性的物质。
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