Nitte (Deemed to be University), Nitte University Centre for Science Education and Research (NUCSER), Department of Food Safety and Nutrition, Paneer Campus, Kotekar-Beeri Road, Deralakatte, Mangalore, 575 018, Karnataka, India.
Curr Nutr Rep. 2023 Dec;12(4):567-580. doi: 10.1007/s13668-023-00492-x. Epub 2023 Aug 29.
PURPOSE OF REVIEW: Fucoxanthin is an orange-red xanthophyll carotenoid found in brown seaweeds and known for its many bioactive properties. In recent years, the bioactive properties of fucoxanthin have been widely explored, making it a compound of immense interest for various health applications like anti-cancer, anti-tumour, anti-diabetic and anti-obesity properties. However, the poor bioavailability and instability of fucoxanthin in the gastrointestinal tract have major limitations. Encapsulation is a promising approach to overcome these challenges by enclosing fucoxanthin in a protective layer, such as liposomes or nano-particles. Encapsulation can improve the stability of fucoxanthin by protecting it from exposure to heat, pH, illumination, gastric acids and enzymes that can accelerate its degradation. RECENT FINDINGS: Studies have shown that lipid-based encapsulation systems such as liposomes or nano-structured lipid carriers may solubilise fucoxanthin and enhance its bioavailability (from 25 to 61.2%). In addition, encapsulation can also improve the solubility of hydrophobic fucoxanthin, which is important for its absorption and bioavailability. This review highlights the challenges involved in the absorption of fucoxanthin in the living system, role of micro- and nano-encapsulation of fucoxanthin and their potential to enhance intestinal absorption.
综述目的:褐藻中存在一种橙红色的类胡萝卜素叶黄素——岩藻黄质,其具有多种生物活性。近年来,岩藻黄质的生物活性得到了广泛的探索,使其成为具有抗癌、抗肿瘤、抗糖尿病和抗肥胖特性等各种健康应用的极具吸引力的化合物。然而,岩藻黄质在胃肠道中的生物利用度差和不稳定性是主要的限制因素。通过将岩藻黄质包裹在保护层中(如脂质体或纳米颗粒),可以实现封装,这是克服这些挑战的一种很有前途的方法。封装可以通过保护岩藻黄质免受热、pH 值、光照、胃酸和可以加速其降解的酶的暴露来提高其稳定性。
最新研究发现:脂质基封装系统,如脂质体或纳米结构化脂质载体,可能使岩藻黄质溶解并提高其生物利用度(从 25%提高到 61.2%)。此外,封装还可以提高疏水性岩藻黄质的溶解度,这对其吸收和生物利用度很重要。本文综述了岩藻黄质在生物系统中吸收的挑战,岩藻黄质的微纳米封装的作用及其增强肠道吸收的潜力。
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