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岩藻黄质,一种功能性食品成分:生物利用度的挑战。

Fucoxanthin, a Functional Food Ingredient: Challenges in Bioavailability.

机构信息

Nitte (Deemed to be University), Nitte University Centre for Science Education and Research (NUCSER), Department of Food Safety and Nutrition, Paneer Campus, Kotekar-Beeri Road, Deralakatte, Mangalore, 575 018, Karnataka, India.

出版信息

Curr Nutr Rep. 2023 Dec;12(4):567-580. doi: 10.1007/s13668-023-00492-x. Epub 2023 Aug 29.


DOI:10.1007/s13668-023-00492-x
PMID:37642932
Abstract

PURPOSE OF REVIEW: Fucoxanthin is an orange-red xanthophyll carotenoid found in brown seaweeds and known for its many bioactive properties. In recent years, the bioactive properties of fucoxanthin have been widely explored, making it a compound of immense interest for various health applications like anti-cancer, anti-tumour, anti-diabetic and anti-obesity properties. However, the poor bioavailability and instability of fucoxanthin in the gastrointestinal tract have major limitations. Encapsulation is a promising approach to overcome these challenges by enclosing fucoxanthin in a protective layer, such as liposomes or nano-particles. Encapsulation can improve the stability of fucoxanthin by protecting it from exposure to heat, pH, illumination, gastric acids and enzymes that can accelerate its degradation. RECENT FINDINGS: Studies have shown that lipid-based encapsulation systems such as liposomes or nano-structured lipid carriers may solubilise fucoxanthin and enhance its bioavailability (from 25 to 61.2%). In addition, encapsulation can also improve the solubility of hydrophobic fucoxanthin, which is important for its absorption and bioavailability. This review highlights the challenges involved in the absorption of fucoxanthin in the living system, role of micro- and nano-encapsulation of fucoxanthin and their potential to enhance intestinal absorption.

摘要

综述目的:褐藻中存在一种橙红色的类胡萝卜素叶黄素——岩藻黄质,其具有多种生物活性。近年来,岩藻黄质的生物活性得到了广泛的探索,使其成为具有抗癌、抗肿瘤、抗糖尿病和抗肥胖特性等各种健康应用的极具吸引力的化合物。然而,岩藻黄质在胃肠道中的生物利用度差和不稳定性是主要的限制因素。通过将岩藻黄质包裹在保护层中(如脂质体或纳米颗粒),可以实现封装,这是克服这些挑战的一种很有前途的方法。封装可以通过保护岩藻黄质免受热、pH 值、光照、胃酸和可以加速其降解的酶的暴露来提高其稳定性。

最新研究发现:脂质基封装系统,如脂质体或纳米结构化脂质载体,可能使岩藻黄质溶解并提高其生物利用度(从 25%提高到 61.2%)。此外,封装还可以提高疏水性岩藻黄质的溶解度,这对其吸收和生物利用度很重要。本文综述了岩藻黄质在生物系统中吸收的挑战,岩藻黄质的微纳米封装的作用及其增强肠道吸收的潜力。

相似文献

[1]
Fucoxanthin, a Functional Food Ingredient: Challenges in Bioavailability.

Curr Nutr Rep. 2023-12

[2]
Fucoxanthin activities motivate its nano/micro-encapsulation for food or nutraceutical application: a review.

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[3]
Fucoxanthin, a marine carotenoid present in brown seaweeds and diatoms: metabolism and bioactivities relevant to human health.

Mar Drugs. 2011-10-10

[4]
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[5]
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[6]
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[7]
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[8]
Monocaprin Enhances Bioavailability of Fucoxanthin in Diabetic/Obese KK- Mice.

Mar Drugs. 2022-7-7

[9]
The stability and bioaccessibility of fucoxanthin in spray-dried microcapsules based on various biopolymers.

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[10]
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引用本文的文献

[1]
Fucoxanthin-Loaded Solid Lipid Nanoparticles Exert Potent Therapeutic Efficacy in Combating High-Fat Diet Induced Obesity in Mice.

Int J Mol Sci. 2025-5-29

[2]
Promising benefits of six-month microalgae supplementation on cognitive function and inflammation in healthy older adults with age-associated memory impairment.

Front Aging. 2025-4-30

[3]
Fucoxanthin from Targeting PANoptosis and Ferroptosis Pathways: Insights into Its Therapeutic Potential Against Ovarian Cancer.

Mar Drugs. 2025-3-12

[4]
The role of -zeatin in enhancing high-temperature resistance and fucoxanthin biosynthesis in .

Appl Environ Microbiol. 2024-6-18

本文引用的文献

[1]
The stability and bioaccessibility of fucoxanthin in spray-dried microcapsules based on various biopolymers.

RSC Adv. 2018-10-15

[2]
Fucoxanthin activities motivate its nano/micro-encapsulation for food or nutraceutical application: a review.

Food Funct. 2020-11-18

[3]
Modulation of Gut Microbiota by Fucoxanthin During Alleviation of Obesity in High-Fat Diet-Fed Mice.

J Agric Food Chem. 2020-5-6

[4]
Purification of fucoxanthin from Sargassum wightii Greville and understanding the inhibition of angiotensin 1-converting enzyme: An in vitro and in silico studies.

Int J Biol Macromol. 2020-1-16

[5]
Health benefits of fucoxanthin in the prevention of chronic diseases.

Biochim Biophys Acta Mol Cell Biol Lipids. 2020-1-10

[6]
Fucoxanthin and Rosmarinic Acid Combination Has Anti-Inflammatory Effects through Regulation of NLRP3 Inflammasome in UVB-Exposed HaCaT Keratinocytes.

Mar Drugs. 2019-8-1

[7]
Effects of temperature, light, and pH on the stability of fucoxanthin in an oil-in-water emulsion.

Food Chem. 2019-4-1

[8]
Medicinal plants with concomitant anti-diabetic and anti-hypertensive effects as potential sources of dual acting therapies against diabetes and hypertension: A review.

J Ethnopharmacol. 2019-2-12

[9]
Neuroprotective role of fucoxanthin against cerebral ischemic/reperfusion injury through activation of Nrf2/HO-1 signaling.

Biomed Pharmacother. 2018-7-24

[10]
Fucoxanthin bioavailability from fucoxanthin-fortified milk: In vivo and in vitro study.

Food Chem. 2018-3-13

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