Geraldes Catarina, Tavares Luís, Gil Solange, Oliveira Manuela
Department of Animal Health, Centre for Interdisciplinary Research in Animal Health (CIISA), Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal.
Associate Laboratory for Animal and Veterinary Science (AL4AnimalS), Lisbon, Portugal.
Microb Drug Resist. 2023 Oct;29(10):456-476. doi: 10.1089/mdr.2023.0074. Epub 2023 Aug 29.
Hospital-acquired infections are a rising problem with consequences for patients, hospitals, and health care workers. Biocides can be employed to prevent these infections, contributing to eliminate or reduce microorganisms' concentrations at the hospital environment. These antimicrobials belong to several groups, each with distinct characteristics that need to be taken into account in their selection for specific applications. Moreover, their activity is influenced by many factors, such as compound concentration and the presence of organic matter. This article aims to review some of the chemical biocides available for hospital infection control, as well as the main factors that influence their efficacy and promote susceptibility decreases, with the purpose to contribute for reducing misusage and consequently for preventing the development of resistance to these antimicrobials.
医院获得性感染是一个日益严重的问题，对患者、医院和医护人员都会产生影响。杀菌剂可用于预防这些感染，有助于消除或降低医院环境中微生物的浓度。这些抗菌剂属于几个类别，每个类别都有不同的特性，在为特定应用选择时需要加以考虑。此外，它们的活性受许多因素影响，如化合物浓度和有机物的存在。本文旨在综述一些可用于医院感染控制的化学杀菌剂，以及影响其效力并促使敏感性降低的主要因素，目的是有助于减少误用，从而预防对这些抗菌剂产生耐药性。
