Infectious and Tropical Diseases Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Microbiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Infectious and Tropical Diseases Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Microbiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Clinical Research Development Unit, Sina Educational, Research and Treatment Centre, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
J Hosp Infect. 2021 Nov;117:135-146. doi: 10.1016/j.jhin.2021.09.010. Epub 2021 Sep 22.
A global upsurge in antibiotic-resistant Acinetobacter baumannii requires supervised selection of biocides and disinfectants to avert nosocomial infections by reducing its spread. Moreover, inadequate and improper biocides have been reported as a contributing factor in antimicrobial resistance. Regardless of the manner of administration, a biocidal concentration that does not kill the target bacteria creates a stress response, propagating the resistance mechanisms. This is an essential aspect of the disinfection programme and the overall bio-contamination management plan. Knowing the mechanisms of action of biocides and resistance modalities may open new avenues to discover novel agents. This review describes the mechanisms of action of some biocides, resistance mechanisms, and approaches to study susceptibility/resistance to these agents.
全球范围内对抗生素耐药鲍曼不动杆菌的需求不断增加，这就需要对消毒剂和防腐剂进行监管选择，以减少其传播，从而避免医院感染。此外，据报道，消毒剂的使用不足和不当也是导致抗生素耐药的一个因素。无论采用何种给药方式，如果杀菌浓度不能杀死目标细菌，都会引发细菌的应激反应，从而促进耐药机制的产生。这是消毒方案和整体生物污染管理计划的一个重要方面。了解消毒剂的作用机制和耐药模式可能为发现新的药物开辟新途径。本文综述了一些消毒剂的作用机制、耐药机制以及研究这些药物敏感性/耐药性的方法。
