School of Medicine, Xizang Minzu University, Key Laboratory of High Altitude Hypoxia Environment and Life Health, Joint Laboratory for Research on Active Components and Pharmacological Mechanism of Tibetan Materia Medica of Tibetan Medical Research Center of Tibet, Xianyang 712082, Shaanxi Province, China.
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2023 Aug 25;52(4):451-459. doi: 10.3724/zdxbyxb-2023-0169.
Long non-coding RNAs (lncRNAs) are strongly related to the occurrence and development of digestive tract cancer in human. Firstly, lncRNAs target and regulate the expression of downstream cancer genes to affect the growth, metastasis, apoptosis, metabolism and immune escape of cancer cells. Secondly, lncRNAs are considered to be important regulating factors for lipid metabolism in cancer, which is related to signaling pathways of adipogenesis and involved in the occurrence and development of digestive tract cancer. Finally, lncRNAs have application value in the diagnosis and treatment of digestive tract cancer. For example, lncRNAMALAT1 has been reported as a target for diagnosis and treatment of hepatocellular carcinoma. This article reviews current progress on the regulatory role of lncRNAs in digestive tract cancer, to provide references for the research and clinical application in the prevention and treatment of digestive tract cancer.
长链非编码 RNA（lncRNA）与人消化道癌的发生发展密切相关。首先，lncRNA 靶向并调节下游致癌基因的表达，从而影响癌细胞的生长、转移、凋亡、代谢和免疫逃逸。其次，lncRNA 被认为是癌症中脂质代谢的重要调节因子，与脂肪生成信号通路有关，并参与消化道癌的发生和发展。最后，lncRNA 在消化道癌的诊断和治疗中有应用价值。例如，lncRNAMALAT1 已被报道为肝癌诊断和治疗的靶点。本文综述了 lncRNA 在消化道癌中的调控作用的研究进展，为消化道癌的防治研究和临床应用提供参考。
